Results 11 to 20 of about 45,778 (231)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Metallothionein

Experimental Biology and Medicine, 1987
Early research on metallothionein centered on aspects related to a detoxification role. As our understanding of the complex endocrine control that regulates metallothionein gene expression increases, a wider appreciation of a functional role(s) is emerging.
M A, Dunn, T L, Blalock, R J, Cousins
openaire   +2 more sources

Anti-metallothionein IgG and levels of metallothionein in autistic children with GI disease [PDF]

, 2009
A J RussoMount Saint Mary’s University, Emmitsburg, MD, USAAim: To assess both serum concentration of metallotionein (MT) and anti-metallothionein (anti-MT) immunoglobulin G (IgG) in autistic children with gastrointestinal (GI) symptoms and ...
Anthony Russo, A J Russo
core   +1 more source

Metallothionein expression in feline injection site fibrosarcomas

BMC Veterinary Research, 2023
Background Feline injection site fibrosarcoma is an aggressive and infiltrative tumour arising in the background of chronic inflammation. The aim of this study was to evaluate the expression of metallothionein (I-II) in feline injection site ...
Mateusz Mikiewicz, Katarzyna Paździor-Czapula, Joanna Fiedorowicz, Michał Gesek, Iwona Otrocka-Domagała   +4 more
doaj   +1 more source

Evaluation of metallothionein response in Lymnaea stagnalis pond snail to exposured to trace metals and thiocarbamate fungicide

Біологічні студії, 2019
Pulmonate mollusks posses high uptake rates of dissolved metals and their bonding, mainly Cd, Zn and Cu by the metal-buffering protein, metallothionein (MT).
L. L. Gnatyshyna
doaj   +1 more source

The Evolution of Insect Metallothioneins [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2020
ABSTRACT Metallothioneins (MTs) are a family of cysteine-rich metal-binding proteins that are important in the chelating and detoxification of toxic heavy metals. Until now, the short length and the low sequence complexity of MTs has hindered the possibility of any phylogenetic reconstruction, hampering the study of ...
Mei Luo, Cédric Finet, Haosu Cong, Hong-yi Wei, Henry Chung   +4 more
openaire   +2 more sources

METALLOTHIONEIN PADA HATI IKAN SEBAGAI BIOMARKER PENCEMARAN KADMIUM (Cd) DI PERAIRAN KALIGARANG SEMARANG (Metallothionein in The Fish Liver as Biomarker of Cadmium (Cd) Pollution in Kaligarang River Semarang)

Jurnal Manusia dan Lingkungan, 2015
ABSTRAK Penanda dini pencemaran kadmium  di sungai Kaligarang perlu diketahui sebagai alat monitoring pencemaran logam berat,  mengingat sungai Kaligarang digunakan untuk memenuhi kebutuhan air minum bagi masyarakat kota Semarang.
Nur Kusuma Dewi, Purwanto Purwanto, Henna Rya Sunoko   +2 more
doaj   +1 more source

Bacterium-Based Heavy Metal Biosorbents: Enhanced Uptake of Cadmium by E. coli Expressing a Metallothionein Fused to β-Galactosidase

BioTechniques, 2002
We investigated the potential utility of a recombinant E. coli that expresses the human metallothionein II gene as a fusion protein with β-galactosidase as a heavy metal biosorbent. E.
N. Yoshida, T. Kato, T. Yoshida, K. Ogawa, M. Yamashita, Y. Murooka   +5 more
doaj   +1 more source

Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum

Journal of Education, Health and Sport, 2018
In an experiment on white wild-type laboratory rats, it was shown that 90 minutes after intraperitoneal administration of cisplatin at a dose of 4 mg / kg as a solution heated to 43 °C, the integral level of metallothionein significantly increased in the
E. D. Pykhtieieva, E. G. Pykhtieieva, A. I. Gozhenko   +2 more
doaj   +3 more sources

AzuR From the SmtB/ArsR Family of Transcriptional Repressors Regulates Metallothionein in Anabaena sp. Strain PCC 7120

Frontiers in Microbiology, 2022
Metallothioneins (MTs) are cysteine-rich, metal-sequestering cytosolic proteins that play a key role in maintaining metal homeostasis and detoxification.
T. V. Divya, T. V. Divya, Celin Acharya, Celin Acharya   +3 more
doaj   +1 more source