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The role of glutathione transferases in TNT detoxification [PDF]
Glutathione transferases (GSTs) are multi-functional enzymes with an important role in plant biochemical mechanisms of xenobiotic detoxification. The GSTs have been extensively studied due to their ability to detoxify herbicides; recently they have been ...
Gunning, Vanda
core +6 more sources
Glutathione is a simple sulfur compound composed of three amino acids and the major non-protein thiol in many organisms, including plants. The functions of glutathione are manifold but notably include redox-homeostatic buffering. Glutathione status is modulated by oxidants as well as by nutritional and other factors, and can influence protein structure
Graham, Noctor +4 more
openaire +2 more sources
Multimodal neuroimaging data of various brain disorders provides valuable information to understand brain function in health and disease. Various neuroimaging-based databases have been developed that mainly consist of volumetric magnetic resonance ...
Pravat K. Mandal +16 more
doaj +1 more source
Glutathione and mitochondria [PDF]
Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including ...
Ribas, Vicent +2 more
openaire +4 more sources
GLUTATHIONE DETERMINATION AND A STUDY OF THE ACTIVITY OF GLUTATHIONE-PEROXIDASE, GLUTATHIONE-TRANSFERASE, AND GLUTATHIONE-REDUCTASE IN RENAL TRANSPLANTS [PDF]
The aim of this work is to study the temporary variation of oxidative stress in renal transplants, both in plasma and in erythrocytes (CR). In order to do so, we determined total glutathione (GST) levels, both oxidized (GSSG) and reduced (GSH), and the activity of enzymes, glutathione peroxidase (G-px), glutathione reductase (G-red) and glutathione ...
Vega, L. de +5 more
openaire +3 more sources
The Role of Glutathione Transferases in the Detoxification of TNT [PDF]
Manufacture, use, storage and improper disposal of the explosive 2,4,6-trinitrotoluene (TNT) have led to widespread, global contamination of soil and groundwater.
Sparrow, Helen
core +6 more sources
Changes were studied in the endogenous level of glutathione (total and oxidised), and in the amount of free thiol groups as caused by the herbicide atrazine on two species of plants with different sensitivity to it.
Lyuba P.-E. Miteva +3 more
doaj +1 more source
Intracellular glutathione pools are heterogeneously concentrated [PDF]
Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione ...
Christine Tachibana +8 more
core +1 more source
Prodrug Approach for Increasing Cellular Glutathione Levels
Reduced glutathione (GSH) is the most abundant non-protein thiol in mammalian cells and the preferred substrate for several enzymes in xenobiotic metabolism and antioxidant defense.
Ivana Cacciatore +4 more
doaj +1 more source
Objective: To compare the level of glutathione (GSH) and oxidized glutathione (GSSG), the ratio of GSH/GSSG and the concentration of albumin in plasma of patients with complicated and un-complicated falciparum malaria.
Loeki Enggar Fitri +9 more
doaj +1 more source

