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Glutathione [PDF]

open access: yesThe Arabidopsis Book, 2011
Glutathione is a simple sulfur compound composed of three amino acids and the major non-protein thiol in many organisms, including plants. The functions of glutathione are manifold but notably include redox-homeostatic buffering. Glutathione status is modulated by oxidants as well as by nutritional and other factors, and can influence protein structure
Graham, Noctor   +4 more
openaire   +2 more sources

Glutathione and mitochondria [PDF]

open access: yesFrontiers in Pharmacology, 2014
Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including ...
Ribas, Vicent   +2 more
openaire   +4 more sources

GLUTATHIONE DETERMINATION AND A STUDY OF THE ACTIVITY OF GLUTATHIONE-PEROXIDASE, GLUTATHIONE-TRANSFERASE, AND GLUTATHIONE-REDUCTASE IN RENAL TRANSPLANTS [PDF]

open access: yesRenal Failure, 2002
The aim of this work is to study the temporary variation of oxidative stress in renal transplants, both in plasma and in erythrocytes (CR). In order to do so, we determined total glutathione (GST) levels, both oxidized (GSSG) and reduced (GSH), and the activity of enzymes, glutathione peroxidase (G-px), glutathione reductase (G-red) and glutathione ...
Vega, L. de   +5 more
openaire   +3 more sources

Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine

open access: yesAntioxidants, 2022
Extensive research has changed the understanding of oxidative stress that has been linked to every major disease. Today we distinguish oxidative eu- and distress, acknowledging that redox modifications are crucial for signal transduction in the form of ...
Paola Loreto Palacio   +3 more
doaj   +1 more source

5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense

open access: yesAntioxidants, 2022
Oxidative stress is a major mediator of adverse outcomes in acute kidney injury (AKI). Deficiency of micronutrients, such as folate, is common in AKI. Our previous study reported that AKI impaired kidney reabsorption of folate and decreased plasma folate
Charith U. B. Wijerathne   +3 more
doaj   +1 more source

Effect of a significant deficiency in some antioxidants on semen parameters in cases of male infertility in Diyala Province, Iraq [PDF]

open access: yesJournal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Scientific evidence indicates that oxidative stress (OS) is a major factor in the etiology of male infertility. OS occurs when there is an imbalance between reactive oxygen species (ROS) and protective antioxidants.
Luay Qasim Abdulhameed
doaj  

Metabolomic Analysis of Carbohydrate and Amino Acid Changes Induced by Hypoxia in Naked Mole-Rat Brain and Liver

open access: yesMetabolites, 2022
Hypoxia poses a major physiological challenge for mammals and has significant impacts on cellular and systemic metabolism. As with many other small rodents, naked mole-rats (NMRs; Heterocephalus glaber), who are among the most hypoxia-tolerant mammals ...
Hang Cheng   +5 more
doaj   +1 more source

Liposomes as Carriers for the Delivery of Efavirenz in Combination with Glutathione—An Approach to Combat Opportunistic Infections

open access: yesApplied Sciences, 2022
Human immunodeficiency virus (HIV)-infected individuals display an enhanced production of reactive oxygen species (ROS). This reduction of antioxidant capacity in host tissues has been related to the decrease in total levels of ROS scavengers such as ...
Vanaja Kenchappa   +3 more
doaj   +1 more source

Investigation of the thiol-disulfide system state of rats with encephalopathy caused by the effect of antituberculous drugs

open access: yesPatologìâ, 2019
Objective. To determine in an experimental study the nature of changes in the status of the thiol-disulfide system of rats with encephalopathy, due to the influence of complex of anti-tuberculosis drugs for the treatment of chemoresistant tuberculosis ...
A. V. Levich   +3 more
doaj   +1 more source

Oxidative Stress in Relation to Aging and Exercise

open access: yesEncyclopedia, 2022
Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, resulting in disruption of redox signaling and control and causing molecular damage.
Dimphna Verhaegen   +3 more
doaj   +1 more source

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