Results 41 to 50 of about 554,348 (295)

Hormonal, antioxidant, and body composition differences in national level male athletes: a comparative study of aerobic and anaerobic training

Frontiers in Sports and Active Living
BackgroundCompetitive athletes exhibit distinct physiological adaptations depending on their sport type and training techniques. These variations influence body composition, hunger-regulating hormones, and antioxidant defense mechanisms, which ...
Manar Burhan Jaradat, Eyyad Maghayreh, Waqar Husain, Khaled Trabelsi, Khaled Trabelsi, Khaled Trabelsi, Adam Amawi, Haitham Jahrami, Haitham Jahrami, Hadeel Ali Ghazzawi   +9 more
doaj   +1 more source

Glutathione transferases in soybean glycine max (L.) Merr [PDF]

, 1999
Glutathione transferases, also known as Glutathione S-transferases (GSTs), are a diverse group of enzymes that catalyse the conjugation of the tri-peptide glutathione to a wide range of electrophilic substrates.
Andrews, Christopher John
core  

The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission [PDF]

, 2009
1Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp.
Vega-Rodríguez Joel, Franke-Fayard Blandine, Coppens Isabelle, Waters Andrew P., Dinglasan, R.R., Andrew P. Waters, Joel Vega-Rodríguez, Rhoel R. Dinglasan, Jacobs-Lorena Marcelo, José F Rodríguez-Orengo, Jacobs-Lorena, M., Rodríguez-Orengo José F., Blandine Franke-Fayard, Chris J. Janse, Vega-Rodriguez, J., Isabelle Coppens, José F. Rodríguez-Orengo, Serrano Adelfa E., Adelfa E. Serrano, Janse, C.J., Serrano, A.E., Rhoel R Dinglasan, Prakash Srinivasan, Waters, A., Adelfa E Serrano, Marcelo Jacobs-Lorena, Pastrana-Mena Rebecca, Janse Chris J., Chris J Janse, Dinglasan Rhoel R., Rodriguez-Orengo, J.F., Srinivasan, P., Pastrana-Mena, R., Rebecca Pastrana-Mena, Franke-Fayard, B., Andrew P Waters   +35 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Saibal K. Biswas, Biswas, Saibal K, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells

Antioxidants, 2018
Cystinosin is a lysosomal transmembrane protein which facilitates transport of the disulphide amino acid cystine (CySS) from the lysosomes of the cell.
Rodolfo Sumayao, Philip Newsholme, Tara McMorrow   +2 more
doaj   +1 more source

Role of Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade

Frontiers in Plant Science, 2021
Plant growth regulators have an important role in various developmental processes during the life cycle of plants. They are involved in abiotic stress responses and tolerance.
Saima Aslam, Nadia Gul, Mudasir A. Mir, Mohd. Asgher, Nadiah Al-Sulami, Aala A. Abulfaraj, Sameer Qari   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Exogenous Ergothioneine and Glutathione Limit Postharvest Senescence of Arugula

Antioxidants
Arugula is susceptible to postharvest deterioration. We tested the impact of exogenous antioxidant (i.e., ergothioneine and glutathione) dip solutions on arugula quality during storage at 4 °C or 10 °C for up to 17 days relative to a non-antioxidant ...
Dhanya Sivakumar, Gale Bozzo
doaj   +1 more source