Results 41 to 50 of about 775,294 (358)
The Cold Atmospheric Plasma Inhibits Cancer Proliferation Through Reducing Glutathione Synthesis
Molecules(1) Objective: Cold atmospheric plasma (CAP) is a safe and effective alternative to radiotherapy for cancer treatment. Its anticancer effects are attributed to increased intracellular reactive oxygen species (ROS).
Qiyu Yang +6 more
doaj +1 more source
Antioxidants, 2019 Reactive oxygen species (ROS) generation is a usual phenomenon in a plant both under a normal and stressed condition. However, under unfavorable or adverse conditions, ROS production exceeds the capacity of the antioxidant defense system.
M. Hasanuzzaman +6 more
semanticscholar +1 more source
Glutathione transferases in soybean glycine max (L.) Merr [PDF]
, 1999 Glutathione transferases, also known as Glutathione S-transferases (GSTs), are a diverse group of enzymes that catalyse the conjugation of the tri-peptide glutathione to a wide range of electrophilic substrates.
Andrews, Christopher John
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Pharmacology Research & PerspectivesParkinson's disease (PD) is the most prevalent neurodegenerative disease. Previously, it was believed that aberrant iron metabolism, leading to ferroptosis due to glutathione (GSH) depletion, excessive Ca2+ influx, mitochondrial (mROS), and cytosolic ...
Elif Güzel +2 more
doaj +1 more source
Frontiers in Sports and Active LivingBackgroundCompetitive athletes exhibit distinct physiological adaptations depending on their sport type and training techniques. These variations influence body composition, hunger-regulating hormones, and antioxidant defense mechanisms, which ...
Manar Burhan Jaradat +9 more
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Glutathione transferases in maize (zea mays) [PDF]
, 1998 The glutathione transferases (GSTs) of maize have been the most studied GSTs in plants, however much is still not known about these enzymes. In the course of the current study six GST subunits (Zm GSTs I, II and III, which have been reported previously ...
Dixon, D.P., Dixon, David Peter
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Antioxidants, 2018 Cystinosin is a lysosomal transmembrane protein which facilitates transport of the disulphide amino acid cystine (CySS) from the lysosomes of the cell.
Rodolfo Sumayao +2 more
doaj +1 more source