Results 31 to 40 of about 775,294 (358)

Investigation of the thiol-disulfide system state of rats with encephalopathy caused by the effect of antituberculous drugs

Patologìâ, 2019
Objective. To determine in an experimental study the nature of changes in the status of the thiol-disulfide system of rats with encephalopathy, due to the influence of complex of anti-tuberculosis drugs for the treatment of chemoresistant tuberculosis ...
A. V. Levich, N. O. Skorokhodova, D. H. Zhyvytsia, Yu. V. Prosvetov   +3 more
doaj   +1 more source

Oxidative Stress in Relation to Aging and Exercise

Encyclopedia, 2022
Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, resulting in disruption of redox signaling and control and causing molecular damage.
Dimphna Verhaegen, Kelly Smits, Nádia Osório, Armando Caseiro   +3 more
doaj   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Saibal K. Biswas, Biswas, Saibal K, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

N-acetylcysteine in Kidney Disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness

Kidney International Reports
N-acetylcysteine (NAC) has shown beneficial effects in both acute kidney disease and chronic kidney disease (CKD) in preclinical and clinical studies.
Estefani Y. Hernández-Cruz, Omar E. Aparicio-Trejo, Fadi A. Hammami, Daniel Bar-Shalom, Martin Tepel, Jose Pedraza-Chaverri, Alexandra Scholze   +6 more
doaj   +1 more source

Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation [PDF]

, 2002
Background/Aim: The generation of reactive oxygen species by activated Kupffer cells (KC) may contribute to reperfusion injury of the liver during liver transplantation or resection.
Schauer, R., Rolf Schauer, Andreas Baron, Christian Steib, Ebensberger, S., Stefan Ebensberger, Manfred Bilzer, Steib, C., Alexander L. Gerbes, Baron, A., Bilzer, M., Gerbes, Alexander L.   +11 more
core   +1 more source

Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach

, 2010
Oxidative stress is often associated to inactivity-mediated skeletal muscle atrophy. Glutathione is one of the major antioxidant systems stimulated, both at muscular and systemic level, by activation of oxidative processes.
DALLA LIBERA L, Francesco Agostini, Biolo, Gianni, JURDANA M, Mihaela Jurdana, Sara Mazzucco, BIOLO G., Agostini, Francesco, Jörn Rittweger, Mazzucco, Sara, Jurdana, Mihaela, Luciano Dalla Libera, Narici, Marco, Gianni Biolo, Dalla Libera, Luciano, NARICI M, MEKJAVIC IB, Rittweger, Jörn, AGOSTINI F, Igor B. Mekjavic, Pisot, Rado, PISOT R, Mekjavic, Igor, MAZZUCCO S, Gorza, Luisa, Rado Pišot, RITTWEGER J, Marco Narici, Luisa Gorza, Gorza L   +29 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Maintaining the Quality of Chico Fruit (Manilkara zapota) during Storage Using Amino Acids (Phenylalanine, Glutathione, and L-arginine) and Growth Regulator (Melatonin) [PDF]

مجله پژوهش‌های علوم و صنایع غذایی ایران
IntroductionSapodilla is a tropical fruit well-known for its sweet taste and soft texture. It is a fruit that continues to ripen naturally after being harvested.
Salimeh Ebrahimi Meymand, Leila Jafari, Abdolmajid Mirzaalian Dastjerdi, Asghar Ramazanian   +3 more
doaj   +1 more source

Glutathione S-Transferases in Cancer

Antioxidants, 2021
In humans, the glutathione S-transferases (GST) protein family is composed of seven members that present remarkable structural similarity and some degree of overlapping functionalities.
R. Singh, Katie M. Reindl
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source