Results 21 to 30 of about 569,398 (304)

Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]

, 2015
Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Paromita Majumder, Majumder, P, Duchen, MR, Jonathan E. Gale, Michael R. Duchen, Gale, JE   +5 more
core   +1 more source

Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine

Antioxidants, 2022
Extensive research has changed the understanding of oxidative stress that has been linked to every major disease. Today we distinguish oxidative eu- and distress, acknowledging that redox modifications are crucial for signal transduction in the form of ...
Paola Loreto Palacio, José R. Godoy, Orhan Aktas, Eva-Maria Hanschmann   +3 more
doaj   +1 more source

5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense

Antioxidants, 2022
Oxidative stress is a major mediator of adverse outcomes in acute kidney injury (AKI). Deficiency of micronutrients, such as folate, is common in AKI. Our previous study reported that AKI impaired kidney reabsorption of folate and decreased plasma folate
Charith U. B. Wijerathne, Kathy K. W. Au-Yeung, Yaw L. Siow, Karmin O   +3 more
doaj   +1 more source

Effect of a significant deficiency in some antioxidants on semen parameters in cases of male infertility in Diyala Province, Iraq [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Scientific evidence indicates that oxidative stress (OS) is a major factor in the etiology of male infertility. OS occurs when there is an imbalance between reactive oxygen species (ROS) and protective antioxidants.
Luay Qasim Abdulhameed
doaj  

Metabolomic Analysis of Carbohydrate and Amino Acid Changes Induced by Hypoxia in Naked Mole-Rat Brain and Liver

Metabolites, 2022
Hypoxia poses a major physiological challenge for mammals and has significant impacts on cellular and systemic metabolism. As with many other small rodents, naked mole-rats (NMRs; Heterocephalus glaber), who are among the most hypoxia-tolerant mammals ...
Hang Cheng, Yiming (Amy) Qin, Rashpal Dhillon, James Dowell, John M. Denu, Matthew E. Pamenter   +5 more
doaj   +1 more source

Liposomes as Carriers for the Delivery of Efavirenz in Combination with Glutathione—An Approach to Combat Opportunistic Infections

Applied Sciences, 2022
Human immunodeficiency virus (HIV)-infected individuals display an enhanced production of reactive oxygen species (ROS). This reduction of antioxidant capacity in host tissues has been related to the decrease in total levels of ROS scavengers such as ...
Vanaja Kenchappa, Ruoqiong Cao, Vishwanath Venketaraman, Guru V. Betageri   +3 more
doaj   +1 more source

Investigation of the thiol-disulfide system state of rats with encephalopathy caused by the effect of antituberculous drugs

Patologìâ, 2019
Objective. To determine in an experimental study the nature of changes in the status of the thiol-disulfide system of rats with encephalopathy, due to the influence of complex of anti-tuberculosis drugs for the treatment of chemoresistant tuberculosis ...
A. V. Levich, N. O. Skorokhodova, D. H. Zhyvytsia, Yu. V. Prosvetov   +3 more
doaj   +1 more source

Oxidative Stress in Relation to Aging and Exercise

Encyclopedia, 2022
Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, resulting in disruption of redox signaling and control and causing molecular damage.
Dimphna Verhaegen, Kelly Smits, Nádia Osório, Armando Caseiro   +3 more
doaj   +1 more source

N-acetylcysteine in Kidney Disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness

Kidney International Reports
N-acetylcysteine (NAC) has shown beneficial effects in both acute kidney disease and chronic kidney disease (CKD) in preclinical and clinical studies.
Estefani Y. Hernández-Cruz, Omar E. Aparicio-Trejo, Fadi A. Hammami, Daniel Bar-Shalom, Martin Tepel, Jose Pedraza-Chaverri, Alexandra Scholze   +6 more
doaj   +1 more source

Metabolites of ethanol as markers of alcohol abuse : glutathione consumption and methionine kinetics in humans [PDF]

, 2004
In the course of the present doctoral studies two projects related to research in alcoholism and relevant for the postgraduate formation of a pharmacist were pursued: one project dealt with the development of analytical tools applicable to the ...
Schmid, Andreas Ulrich
core   +1 more source