Results 21 to 30 of about 45,778 (231)

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts [PDF]

, 2009
In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process.
Rittmeyer, Claudia, Olivier Toussaint, Scheckhuber, Christian Q., Ricardo Gredilla, Bernd O Kolbesen, Heinz D, Boilan, Emmanuelle, Claudia Rittmeyer, Gredilla, Ricardo, Christian Q. Scheckhuber, Emmanuelle Boilan, Heinz D. Osiewacz, Debacq-Chainiaux, Florence, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Christian Q Scheckhuber, Florence Debacq-Chainiaux, Toussaint, Olivier, Kolbesen, Bernd O., Karin Luce, Bernd O. Kolbesen, Heinz D Osiewacz, Grief, Jürgen, Florence Debacq, Jürgen Grief, Luce, Karin   +25 more
core   +2 more sources

Temporal variations in metallothionein concentration and subcellular distribution of metals in gills and digestive glands of the oyster Crassostrea angulata

Scientia Marina, 2010
The metallothionein levels and metal concentrations in whole body, digestive gland and gills of Crassostrea angulata were analyzed in field samples collected from the River Guadalquivir estuary over several years following a mining waste spill upstream ...
Chiara Trombini, Elena Fabbri, Julián Blasco   +2 more
doaj   +1 more source

Copper metallothioneins [PDF]

IUBMB Life, 2017
AbstractMetallothioneins (MTs) are a class of low molecular weight and cysteine‐rich metal binding proteins present in all the branches of the tree of life. MTs efficiently bind with high affinity several essential and toxic divalent and monovalent transition metals by forming characteristic polynuclear metal‐thiolate clusters within their structure ...
Jenifer, Calvo, Hunmin, Jung, Gabriele, Meloni   +2 more
openaire   +2 more sources

Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect

Frontiers in Pharmacology, 2021
Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers.
Juan A. Rubiolo, Juan A. Rubiolo, Emilio Lence, Concepción González-Bello, María Roel, José Gil-Longo, Manuel Campos-Toimil, Manuel Campos-Toimil, Eva Ternon, Olivier P. Thomas, Antonio González-Cantalapiedra, Henar López-Alonso, Mercedes R. Vieytes, Luis M. Botana   +13 more
doaj   +1 more source

Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus

International Journal of Science and Engineering, 2013
Zinc is an essential trace element involving in the activity of more than 300 enzymes and proteins of human body. One important role of zinc is to improve metallothionein protein binding heavy metals and functioning as heavy metal detoxification ...
Budi Santosa, Hertanto Wahyu Subagyo, Lisyani S, Henna Rya Sunoko   +3 more
doaj   +1 more source

Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

Diagnostic Pathology, 2012
Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice, Yenicesu GoncaImir, Arici Sema, Cetin Meral, Tuncer Ersin, Cetin Ali   +5 more
doaj   +1 more source

Expression of biomarkers connected to endocrine disruption in Cottus gobio and Salmo trutta fario in relation to sewage treatment plant-efflux and pesticides

Frontiers in Environmental Science, 2022
The increasing efflux on a large scale of organic contaminants holding endocrine disrupting activity from sewage treatment plants produces detrimental biological effects to various fish species.
Michael Niederwanger, Josef Wieser, Melanie Thaler, Agnes Felber, Katja Schmölz, Wolfgang Mark, Erich Tasser, Rüdiger Kaufmann, Bernd Pelster   +8 more
doaj   +1 more source

Metallothioneins, a Part of the Retinal Endogenous Protective System in Various Ocular Diseases

Antioxidants, 2023
Metallothioneins are the metal-rich proteins that play important roles in metal homeostasis and detoxification. Moreover, these proteins protect cells against oxidative stress, inhibit proapoptotic mechanisms and enhance cell differentiation and survival.
Daniel Jamrozik, Radosław Dutczak, Joanna Machowicz, Alicja Wojtyniak, Adrian Smędowski, Marita Pietrucha-Dutczak   +5 more
doaj   +1 more source

Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae [PDF]

, 2006
The present investigation evaluates the toxic potential of Cd in larvae of the frog Xenopus laevis after 12 days of exposure to environmentally relevant contamination levels, close to those measured in the river Lot (France).
Gauthier, Laury, Gonzalez, Patrice, Boudou, Alain, Bourdineaud, Jean-Paul, Mouchet, Florence, Baudrimont, Magalie, Cuenot, Y.   +6 more
core   +1 more source

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

Molecular Brain, 2010
Zinc dyshomeostasis has been recognized as an important mechanism for cell death in acute brain injury. An increase in the level of free or histochemically reactive zinc in astrocytes and neurons is considered one of the major causes of death of these ...
Lee Sook-Jeong, Koh Jae-Young
doaj   +1 more source