Results 21 to 30 of about 34,151 (189)

Temporal variations in metallothionein concentration and subcellular distribution of metals in gills and digestive glands of the oyster Crassostrea angulata

Scientia Marina, 2010
The metallothionein levels and metal concentrations in whole body, digestive gland and gills of Crassostrea angulata were analyzed in field samples collected from the River Guadalquivir estuary over several years following a mining waste spill upstream ...
Chiara Trombini, Elena Fabbri, Julián Blasco   +2 more
doaj   +1 more source

Structure of Mammalian Metallothionein [PDF]

Environmental Health Perspectives, 1984
All mammalian metallothioneins characterized contain a single polypeptide chain of 61 amino acid residues, among them 20 cysteines providing the ligands for seven metal-binding sites. Native metallothioneins are usually heterogeneous in metal composition, with Zn, Cd, and Cu occurring in varying proportions.
J H, Kägi, M, Vasák, K, Lerch, D E, Gilg, P, Hunziker, W R, Bernhard, M, Good   +6 more
openaire   +2 more sources

Zinc Supplementation Dosage Variations to Metallothionein Protein Level of Rattus Norvegicus

International Journal of Science and Engineering, 2013
Zinc is an essential trace element involving in the activity of more than 300 enzymes and proteins of human body. One important role of zinc is to improve metallothionein protein binding heavy metals and functioning as heavy metal detoxification ...
Budi Santosa, Hertanto Wahyu Subagyo, Lisyani S, Henna Rya Sunoko   +3 more
doaj   +1 more source

Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect

Frontiers in Pharmacology, 2021
Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers.
Juan A. Rubiolo, Juan A. Rubiolo, Emilio Lence, Concepción González-Bello, María Roel, José Gil-Longo, Manuel Campos-Toimil, Manuel Campos-Toimil, Eva Ternon, Olivier P. Thomas, Antonio González-Cantalapiedra, Henar López-Alonso, Mercedes R. Vieytes, Luis M. Botana   +13 more
doaj   +1 more source

Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

Diagnostic Pathology, 2012
Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice, Yenicesu GoncaImir, Arici Sema, Cetin Meral, Tuncer Ersin, Cetin Ali   +5 more
doaj   +1 more source

Expression of biomarkers connected to endocrine disruption in Cottus gobio and Salmo trutta fario in relation to sewage treatment plant-efflux and pesticides

Frontiers in Environmental Science, 2022
The increasing efflux on a large scale of organic contaminants holding endocrine disrupting activity from sewage treatment plants produces detrimental biological effects to various fish species.
Michael Niederwanger, Josef Wieser, Melanie Thaler, Agnes Felber, Katja Schmölz, Wolfgang Mark, Erich Tasser, Rüdiger Kaufmann, Bernd Pelster   +8 more
doaj   +1 more source

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

Molecular Brain, 2010
Zinc dyshomeostasis has been recognized as an important mechanism for cell death in acute brain injury. An increase in the level of free or histochemically reactive zinc in astrocytes and neurons is considered one of the major causes of death of these ...
Lee Sook-Jeong, Koh Jae-Young
doaj   +1 more source

Metallothioneins, a Part of the Retinal Endogenous Protective System in Various Ocular Diseases

Antioxidants, 2023
Metallothioneins are the metal-rich proteins that play important roles in metal homeostasis and detoxification. Moreover, these proteins protect cells against oxidative stress, inhibit proapoptotic mechanisms and enhance cell differentiation and survival.
Daniel Jamrozik, Radosław Dutczak, Joanna Machowicz, Alicja Wojtyniak, Adrian Smędowski, Marita Pietrucha-Dutczak   +5 more
doaj   +1 more source

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source