The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke [PDF]
Cell Death and Disease, 2021 Remote limb ischemic postconditioning (RLIP) is an experimental strategy in which short femoral artery ischemia reduces brain damage induced by a previous harmful ischemic insult.
Valeria Valsecchi +6 more
doaj +8 more sources
Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells [PDF]
Cells, 2023 (1) Background: Metal homeostasis is an important part of cellular programs and is disrupted when cells are exposed to carcinogenic heavy metals. Metal response is mediated by the metal response element transcription factor MTF-1.
Gregory M. Wright, Joshua C. Black
doaj +6 more sources
A T > G Mutation in the NR5A2 Gene Is Associated With Litter Size in Hu Sheep Through Upregulation of Promoter Activity by Transcription Factor MTF-1 [PDF]
Frontiers in Genetics, 2019 Nuclear receptor subfamily 5 group A member 2 (NR5A2), also referred to as LRH-1 or FTF, is an orphan nuclear hormone receptor that is involved in regulating embryonic development, ovarian granulosa cell differentiation, gonadal sex differentiation, and ...
Yinxia Li +13 more
doaj +3 more sources
The "metal transcription factor" MTF-1: biological facts and medical implications
Swiss Medical Weekly, 2001 Metallothioneins (MTs) are a class of small, cysteine-rich proteins that have an important function in heavy metal metabolism and detoxification and in the management of various forms of cell stress. Several lines of evidence suggest a role for metallothioneins in therapy resistance of malignant tumours, regulation of blood pressure and protection ...
P Lichtlen, W Schaffner
doaj +4 more sources
Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. [PDF]
Metallomics, 2020 Abstract Environmental exposure to metals is known to cause a number of human toxicities including cancer. Metal-responsive transcription factor 1 (MTF-1) is an important component of metal regulation systems in mammalian cells. Here, we describe a novel method to identify chemicals that activate MTF-1 based on microarray profiling data.
Jackson AC +6 more
europepmc +5 more sources
Target gene search for the metal-responsive transcription factor MTF-1 [PDF]
Nucleic Acids Research, 2001 Activation of genes by heavy metals, notably zinc, cadmium and copper, depends on MTF-1, a unique zinc finger transcription factor conserved from insects to human. Knockout of MTF-1 in the mouse results in embryonic lethality due to liver decay, while knockout of its best characterized target genes, the stress-inducible metallothionein genes I and II ...
P Lichtlen, O Georgiev, U Certa
exaly +5 more sources
The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1). [PDF]
Mol Cell Biol, 2011 The gene for Parkin, an E3 ubiquitin ligase, is mutated in some familial forms of Parkinson's disease, a severe neurodegenerative disorder. A homozygous mutant of the Drosophila ortholog of human parkin is viable but results in severe motoric impairment including an inability to fly, female and male sterility, and a decreased life span.
Saini N, Georgiev O, Schaffner W.
europepmc +6 more sources
Correction: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke [PDF]
Cell Death and Disease, 2023 Valeria Valsecchi +6 more
doaj +4 more sources
Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1) [PDF]
Biochemistry and Cell Biology, 2011 Metal-responsive transcription factor-1 (MTF-1) is essential for the induction of genes encoding metallothionein by metals and hypoxia. Here, we studied the mechanism controlling the activation of MTF-1 by hypoxia. Hypoxia activation of Mt gene transcription is dependent on the presence of metal regulatory elements (MREs) in the promoter of Mt genes ...
Carl Seguin
exaly +5 more sources
Biological and Pharmaceutical Bulletin, 2015 Metal responsive element (MRE)-binding transcription factor-1 (MTF-1) is a zinc finger (ZF) transcription factor that plays a key role in heavy metal homeostasis by regulating relevant genes in response to metals. MTF-1 is known to be activated by heavy metals such as Zn and Cd, but the mechanism of activation remains unclear. In the present study, Cys
Shinji Koizumi
exaly +5 more sources