Results 41 to 50 of about 2,530 (148)

Mechanistic role of metal-responsive transcription factor-1 (MTF1) in cadmium-induced prostate carcinogenesis. [PDF]

Int J Biol Sci
Chandrasekaran B, Tyagi B, Tyagi A, Shukla V, Schatz M, Devanarayanan TN, Tyagi N, Damodaran C.   +7 more
europepmc   +3 more sources

Human cells experience a Zn2+ pulse in early G1

Cell Reports, 2023
Summary: Zinc is an essential micronutrient required for all domains of life. Cells maintain zinc homeostasis using a network of transporters, buffers, and transcription factors.
Ananya Rakshit, Samuel E. Holtzen, Maria N. Lo, Kylie A. Conway, Amy E. Palmer   +4 more
doaj   +1 more source

Metformin Protects From Rotenone–Induced Nigrostriatal Neuronal Death in Adult Mice by Activating AMPK-FOXO3 Signaling and Mitigation of Angiogenesis

Frontiers in Molecular Neuroscience, 2020
Parkinson’s disease (PD) is a neurodegenerative disease that affects substantia nigra dopamine neurons. Many studies have documented the role of oxidative stress and angiogenesis in the pathogenesis of PD.
Sabah H. El-Ghaiesh, Sabah H. El-Ghaiesh, Hoda I. Bahr, Afaf T. Ibrahiem, Doaa Ghorab, Suliman Y. Alomar, Noha E. Farag, Noha E. Farag, Sawsan A. Zaitone, Sawsan A. Zaitone   +9 more
doaj   +1 more source

Interactions of zinc- and redox-signaling pathways

Redox Biology, 2021
Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a multitude of physiological functions. There is considerable overlap between the affected events, including signal transduction.
Christopher Hübner, Hajo Haase
doaj   +1 more source

Regulatory circuit of human microRNA biogenesis. [PDF]

PLoS Computational Biology, 2007
miRNAs (microRNAs) are a class of endogenous small RNAs that are thought to negatively regulate protein production. Aberrant expression of many miRNAs is linked to cancer and other diseases.
Ji Lee, Zhihua Li, Rachel Brower-Sinning, Bino John   +3 more
doaj   +1 more source

Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.

PLoS ONE, 2011
The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh, Josephine A Wright, David R Brown   +2 more
doaj   +1 more source

Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization

Redox Biology, 2014
The effectiveness of current treatment for age related macular degeneration (AMD) by targeting one molecule is limited due to its multifactorial nature and heterogeneous pathologies.
Y. Li, X. Liu, T. Zhou, M.R. Kelley, P. Edwards, H. Gao, X. Qiao   +6 more
doaj   +1 more source

Zn-responsive proteome profiling and time-dependent expression of proteins regulated by MTF-1 in A549 cells.

PLoS ONE, 2014
Zinc plays a critical role in many biological processes. However, it is toxic at high concentrations and its homeostasis is strictly regulated by metal-responsive transcription factor 1 (MTF-1) together with many other proteins to protect cells against ...
Wen-jie Zhao, Qun Song, Yan-hong Wang, Ke-jin Li, Li Mao, Xin Hu, Hong-zhen Lian, Wei-juan Zheng, Zi-chun Hua   +8 more
doaj   +1 more source

Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd⁺² or As⁺³ transformed human urothelial cells

Cancer Cell International, 2011
Background Studies have shown that metallothionein 3 (MT-3) is not expressed in normal urothelium or in the UROtsa cell line, but is expressed in urothelial cancer and in tumors generated from the UROtsa cells that have been transformed by cadmium (Cd+2)
Ajjimaporn Amornpan, Zheng Yun, Zhou Xu, Toni Conrad, Garrett Scott H, Somji Seema, Sens Mary, Sens Donald A   +7 more
doaj   +1 more source

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

Small, EarlyView.
This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang, Maximilian Wipplinger, Parastoo Akbarimoghaddam, Raquel Alonso‐Roman, Zoltan Cseresnyes, Axel Dietschmann, Valentin Wegner, Adrian Feile, Yann Bachelot, Maria Warschinke, Mohamed I. Abdelwahab Hassan, Sonnhild Mittag, Otmar Huber, Bernhard Hube, Mark S. Gresnigt, Marc Thilo Figge, Alexander S. Mosig   +16 more
wiley   +1 more source