Results 31 to 40 of about 2,530 (148)
The Drosophila Homolog of Mammalian Zinc Finger Factor MTF-1 Activates Transcription in Response to Heavy Metals [PDF]
Molecular and Cellular Biology, 2001 Metallothioneins (MTs) are short, cysteine-rich proteins for heavy metal homeostasis and detoxification; they bind a variety of heavy metals and also act as radical scavengers. Transcription of mammalian MT genes is activated by heavy metal load via the metal-responsive transcription factor 1 (MTF-1), an essential zinc finger protein whose elimination ...
Bo Zhang +3 more
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Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level [PDF]
Acta Biochimica Polonica, 2015 Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response.
Agata Grzywacz +5 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I) and is also involved in the response to hypoxia and oxidative stress. MTF-1 recognizes a specific DNA sequence motif termed the metal response element (MRE), located in the promoter/enhancer ...
Viola Günther +3 more
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Differential Sensitivity of Zinc Finger Transcription Factors MTF-1, Sp1 and Krox-20 to CpG Methylation of Their Binding Sites [PDF]
Biological Chemistry Hoppe-Seyler, 1996 Cytosine methylation at CpG sites is often negatively correlated with mammalian gene activity. Many transcription factors whose DNA binding site contains one or more CpG dinucleotides are no longer able to efficiently bind DNA when the site is methylated. A notable exception is the zinc finger factor Sp1 which binds DNA and activates transcription even
Freddy Radtke +4 more
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Regulation of Metallothionein Transcription by the Metal-responsive Transcription Factor MTF-1 [PDF]
Journal of Biological Chemistry, 2002 Nurten Saydam +4 more
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyControl of metal ion metabolism in animals is crucial for their survival. In this context, the regulation of metallothioneins (MTs), key proteins in metal metabolism and detoxification, by the metal regulatory transcription factor MTF-1 is well established in vertebrates and Drosophila melanogaster.
Veronika Pedrini‐Martha +4 more
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Heliyon, 2023 Background: Metal-responsive transcription factor-1 performs a necessary position in a range of cancers. It is unknown, though, how the prognosis of patients with low-grade gliomas is related to immune infiltration.
Huaixu Li +5 more
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Frontiers in Oncology, 2021 Metal-regulatory transcription factor-1 (MTF-1) is of importance in maintaining metal homeostasis. Copper exposure considerably stimulates the proliferation of hepatocellular carcinoma (HCC) cells with enhanced MTF-1 expression.
Zhuozhen Lyu +4 more
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Macrophage metallothioneins participate in the antileishmanial activity of antimonials
Frontiers in Parasitology, 2023 Host cell functions that participate in the pharmacokinetics and pharmacodynamics (PK/PD) of drugs against intracellular pathogen infections are critical for drug efficacy.
Deninson Alejandro Vargas +10 more
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