Results 21 to 30 of about 2,530 (148)

Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc [PDF]

Biochemical Journal, 2004
Phenolic antioxidants, such as tBHQ [2,5-di-(t-butyl)-1,4-hydroquinone], induce Mt1 (metallothionein 1) gene expression and accumulation of MT protein. Induction of Mt1 mRNA does not depend on protein synthesis, and correlates with oxidation–reduction functions of the antioxidants.
Yongyi Bi, Richard D. Palmiter, Kristi M. WOOD, Qiang Ma   +3 more
openalex   +4 more sources

The Transcription Factor MTF-1 Mediates Metal Regulation of the Mouse ZnT1 Gene [PDF]

Journal of Biological Chemistry, 2000
Metal regulation of the mouse zinc transporter (ZnT)-1 gene was examined in cultured cells and in the developing conceptus. Zinc or cadmium treatment of cell lines rapidly (3 h) and dramatically (about 12-fold) induced ZnT1 mRNA levels. In cells incubated in medium supplemented with Chelex-treated fetal bovine serum, to remove metal ions, levels of ...
S. Joshua Langmade, Rudravajhala Ravindra, Patrick J. Daniels, Glen K. Andrews   +3 more
openalex   +3 more sources

Original MRE-binding Transcriptional Factor Gene in Normal Humans is ZRF, not MTF-1.

Journal of Health Science, 2001
Metallothionein gene is transcriptionally regulated by heavy metals through cis-acting metal responsive elements (MREs). Two proteins, metal-regulatory transcription factor-1 (MTF-1) and zinc regulatory factor (ZRF), have been isolated and cloned from human cells as MRE-binding transcriptional factor (MREBT). These proteins are almost identical to each
Kayoko Kita, Nobuhiko Miura, Minoru Yoshida, Mitsunobu Matsubara, Yutaka Imai, Akira Naganuma   +5 more
openalex   +3 more sources

Chewing loads alter TMJ metabolism and Zn homeostasis via PIEZO1/ TRPV4 [PDF]

Journal of Biological Engineering
The biomechanical effects of bite forces on a temporomandibular joint within the craniofacial masticatory complex remain unclear. Herein, we will discuss the effect of recovering a hypofunctioning temporomandibular joint using normal bite forces ...
Yongmei Wang, Brandon H. Lee, Zhiyuan Yang, Haochen Ci, Bo Wang, Joshua Levy, Sunita P. Ho   +6 more
doaj   +2 more sources

Mechanism of Metallothionein Gene Activation Mediated by Heavy-metal Dependent Transcription Factor MTF-1

YAKUGAKU ZASSHI, 2007
Transcriptional activation of metallothionein (MT) genes by heavy metals is a valuable system for understanding the functions of MT as well as the cellular response against heavy metals. Although it is now known that heavy metal signals culminating in MT induction converge upon a transcription factor MTF-1, the mechanism underlying the MTF-1 response ...
Fuminori Otsuka, Shotaro Ohno, Kaoru Suzuki, Kazuko Takahashi, Motoyasu Ohsawa, Shinji Koizumi   +5 more
  +6 more sources

Cloned transcription factor MTF‐1 activates the mouse metallothionein I promoter.

The EMBO Journal, 1993
Metallothioneins (MTs) are small cysteine-rich proteins whose structure is conserved from fungi to man. MTs strongly bind heavy metals, notably zinc, copper and cadmium. Upon exposure of cells to heavy metal and other adverse treatments, MT gene transcription is strongly enhanced.
Freddy Radtke, Rainer Heuchel, Oleg Georgiev, Martin Hergersberg, Marisa Gariglio, Zlatko Dembić, W. Schaffner   +6 more
openalex   +4 more sources

A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure. [PDF]

J Appl Toxicol
ABSTRACT Many human activities contribute to the pollution of aquatic ecosystems, primarily through agricultural, industrial, mining, and domestic discharges into water bodies. Fish, being highly sensitive to environmental changes, serve as valuable models for monitoring the health of these ecosystems.
da Luz JZ, de Souza TL, de Almeida Roque A, de Marchi M, Pozzan R, Confortin C, Opuskevitch I, da Silva Ferreira FCA, de Oliveira Ribeiro CA, Neto FF.   +9 more
europepmc   +2 more sources

The transcription factor MTF‐1 is essential for basal and heavy metal‐induced metallothionein gene expression. [PDF]

The EMBO Journal, 1994
We have described and cloned previously a factor (MTF-1) that binds specifically to heavy metal-responsive DNA sequence elements in the enhancer/promoter region of metallothionein genes. MTF-1 is a protein of 72.5 kDa that contains six zinc fingers and multiple domains for transcriptional activation. Here we report the disruption of both alleles of the
Rainer Heuchel, Freddy Radtke, Oleg Georgiev, Gerlinde Stark, Michel Aguet, W. Schaffner   +5 more
openalex   +4 more sources

Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes [PDF]

Genes & Development, 2005
From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elements (MREs). Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a ...
Anand Selvaraj, Kuppusamy Balamurugan, Hasmik Yepiskoposyan, Hao Zhou, Dieter Egli, Oleg Georgiev, Dennis J. Thiele, Walter Schaffner   +7 more
openalex   +4 more sources

NNMT Orchestrates Metabolic-Epigenetic Reprogramming to Drive Macrophage-Myofibroblast Transition in Hypertrophic Scarring. [PDF]

Adv Sci (Weinh)
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Dong X, Guo W, Qian Y, Jin W, Li X, Yang J, Ni Q, Wu S, Li F, Wang H, Li C, Cai H.   +11 more
europepmc   +2 more sources