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mTOR inhibitors in the treatment of cancer
Expert Opinion on Investigational Drugs, 2008The mammalian target of rapamycin (mTOR) is a protein kinase of the phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway with a central role in the control of cell proliferation, survival, mobility and angiogenesis. Dysregulation of mTOR pathway has been found in many human tumours; therefore, the mTOR pathway is considered an important target ...
Angelica, Fasolo, Cristiana, Sessa
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The mTOR Signaling Pathway and mTOR Inhibitors in Cancer: Next-generation Inhibitors and Approaches
Current Molecular MedicineAbstract: mTOR is a serine/threonine kinase that plays various roles in cell growth, proliferation, and metabolism. mTOR signaling in cancer becomes irregular. Therefore, drugs targeting mTOR have been developed. Although mTOR inhibitors rapamycin and rapamycin rapalogs (everolimus, rapamycin, temsirolimus, deforolimus, etc.) and new generation mTOR ...
Buşra AKGÜL +2 more
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mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy
Hematology/Oncology Clinics of North America, 2012Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase. It is ubiquitously expressed in cells and is a therapeutic target for the cancer treatment arsenal. Despite the great responses obtained in tumors addicted to specific mutations or overactivation of key members of the mTOR pathway (HiF1α in RCC, cyclin D1 in MCL, or TSC in SEGA),
Alejandro, Gomez-Pinillos +1 more
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The pleiotropic effects of mTOR inhibitors
Journal of Nephrology, 2004Abstract mTOR is a downstream effector of phosphatidylinositol –3- kinase pathway, which is involved in the regulation of protein synthesis and interacts with cell cycle progression. Sirolimus and everolimus may interfere with mTOR activity after their binding with FK binding protein.
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mTOR Pathway and mTOR Inhibitors as Agents for Cancer Therapy
Current Cancer Drug Targets, 2008Research into mTOR, mammalian Target Of Rapamycin as an important drug target continues to be extremely interesting, both in terms of the increased molecular knowledge being acquired at the basis of various human diseases, and also for possible applications in drug cancer therapy.
Paolo, Baldo +5 more
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Replacing calcineurin inhibitors with mTOR inhibitors in children
Pediatric Transplantation, 2005Abstract: A highly selected subject group comprising pediatric recipients of liver (n = 36) and small intestine alone (n = 1) or multivisceral graft (n = 2) were converted to sirolimus maintenance therapy for tacrolimus‐related side effects (n = 32) or by primary intent (n = 7).
Rakesh, Sindhi +7 more
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Nihon rinsho. Japanese journal of clinical medicine, 2010
Mammalian target of rapamycin (mTOR) protein complex functions as an integration center for various intracellular signaling pathways involving proliferation, cell survival, and angiogenesis. These pathways are frequently abnormally regulated in cancer.
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Mammalian target of rapamycin (mTOR) protein complex functions as an integration center for various intracellular signaling pathways involving proliferation, cell survival, and angiogenesis. These pathways are frequently abnormally regulated in cancer.
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Gan to kagaku ryoho. Cancer & chemotherapy, 2011
Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
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Mammalian target of rapamycin(mTOR)exists downstream in the PI3K/AKT signal transmission pathway that is constantly activated in many cancers. It regulates translation of mRNA that codes for proteins involved in survival signals, such as for the cell cycle and apoptosis, by phosphorylation of p70S6K and 4E-BP1 that are further downstream.
openaire +1 more source