Results 111 to 120 of about 307,707 (316)

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

A comparison of Nordic Red, Holstein-Friesian and Finnish native cattle bulls for beef production and carcass traits

Agricultural and Food Science, 2014
The objective of this study was to determine beef production traits of purebred Nordic Red (NR), Holstein-Friesian (Hol), Eastern Finncattle (EF), Northern Finncattle (NF) and Western Finncattle (WF) bulls.
Arto Kalevi Huuskonen
doaj  

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Activities of MTT Horticulture in 1997-1999

, 2001
vo
Tahvonen, Risto
core  

Novel methods for reducing agricultural nutrient loading and eutrophication [PDF]

, 2010
Maatalouden vesistökuormituksen vähentämiseen on sitouduttu sekä Suomessa että monissa muissa maissa, joiden vesistöt ovat rehevöityneet intensiivisen viljelyn ja kotieläintalouden seurauksena. Lannoituksen säätäminen, jyrkkien rinteiden suojavyöhykkeet,
Chardon, Wim, Ekholm, Petri (eds.), Turtola, Eila (eds.)   +2 more
core  

Hair Follicle Seedling Cryomicroneedles from Hierarchical Microfluidic Organoid on a Chip

Advanced Science, EarlyView.
In this paper, a hierarchical microfluidic chip is developed to produce uniform hair follicle organoids (HFOs) in cryomicroneedles. Cryopreservation agents encapsulate HFOs, preserving viability and hair growth potential. The cryomicroneedles enable simple intradermal transplantation with good skin penetration.
Xinyue Cao, Dongyu Xu, Minhui Lu, Yuanjin Zhao   +3 more
wiley   +1 more source

Sadonkorjuun ajoittuminen vaikuttaa porkkanan varastokestävyyteen

, 1997
vokMyynti: MTT puutarhatuotannon tutkimuslaitos. Hinta: 5 raportttia yht.
Suojala, Terhi, Aaltonen, Marja
core  

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Performance of growing and finishing dairy bulls offered diets based on whole-crop barley silage with or without protein supplementation relative to a grass silage-based diet

Agricultural and Food Science, 2013
This study was conducted to examine the performance of growing dairy bulls offered diets based on whole-crop barley silage with or without protein supplementation when compared to a grass silage-based diet.
Arto Kalevi Huuskonen
doaj