Results 71 to 80 of about 307,707 (316)

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Moderni 100-vuotias suuntaa tulevaisuuteen. Maatalouden kannattavuuskirjanpidon juhlajulkaisu [PDF]

, 2013
vokSaatavana MTT ...
Ahlstedt, Jaana (toim.), Nurro, Minna (toim.), Latukka, Arto (toim.)   +2 more
core  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Muuttolinnut

, 2013
Blogikirjoitus MTT Elo ...
Jalli, Marja
core  

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

A comparison of purebred Holstein-Friesian and Holstein-Friesian × beef breed bulls for beef production and carcass traits

Agricultural and Food Science, 2013
The objective of this study was to determine beef production traits of purebred Holstein-Friesian (Hol) and Hol×beef breed crossbred bulls. The data collected from slaughterhouses included observations of 87323 purebred Hol, 783 Hol×Aberdeen angus (Hol ...
Arto Kalevi Huuskonen, Maiju Pesonen, Hilkka Kämäräinen, Risto Kauppinen   +3 more
doaj  

Genetic variation in meat production related traits in reindeer (Rangifer t. tarandus)

Rangifer, 2014
In reindeer husbandry, animal breeding could offer tools for improving productivity by selection. The traits affecting meat production efficiency are primarily related to calf growth and survival, and to dam’s longevity and lifetime ability to raise ...
Kirsi Muuttoranta, Øystein Holand, Knut H. Røed, Miika Tapio, Mauri Nieminen, Asko Mäki-Tanila   +5 more
doaj   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Heritability of sow longevity and lifetime prolificacy in Finnish Yorkshire and Landrace pigs

Agricultural and Food Science, 2013
The objective of this study was to estimate genetic parameters for longevity traits in Finnish pig populations. Analyzed traits were length of productive herd life (LPL), total number of parities (TNP), total number of piglets born (TNB), total number ...
Marja-Liisa Sevón-Aimonen, Pekka Uimari
doaj  

Genetic and environmental effects affecting the variation in birth date and birth weight of reindeer calves

Rangifer, 2013
The factors causing variation in birth date and birth weight were analysed from the data from an experimental reindeer herd consisting of 1136 calves with parental information. The traits had coefficient of variation of 37 and 14%, respectively.
Kirsi Muuttoranta, Øystein Holand, Knut H. Røed, Miika Tapio, Mauri Nieminen, Asko Mäki-Tanila   +5 more
doaj   +1 more source