Results 51 to 60 of about 307,707 (316)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Profitability bookkeeping in the reindeer husbandry

Rangifer, 2007
See extended abstract in Full ...
Arto Latukka, Olli Rantala, Jukka Tauriainen   +2 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Strategic objectives and development plans of beginning farmers

Agricultural and Food Science, 2012
Taking over the management and ownership of a farm contributes positively to farm growth but little is known about how farmers succeed after the starting phase.
Leena Rantamäki-Lahtinen, Minna Katriina Väre   +1 more
doaj  

Evaluation of concentrate factors affecting silage intake of dairy cows: a development of the relative total diet intake index

Animal, 2008
The aim of this work was to develop an index describing the relative intake of the total diet by dairy cows, and hence the ability to predict intake responses to changes in both forage and concentrate variables.
P. Huhtanen, M. Rinne, J. Nousiainen
doaj   +1 more source

A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior [PDF]

, 2013
Background: One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real practical interest.
Radeke, Heinfried H., Cristina Dehelean, Pînzaru, Simona Cîntă, Dehelean, Cristina, Melania F Munteanu, Barbu-Tudoran, Lucian, Alexandra Falamas, Danciu, Corina, Codruta Soica, Falamas, Alexandra, Corina Danciu, Simona Pînzaru, Florina Bojin, Munteanu, Melania F., Heinfried Radeke, Lucian Barbu-Tudoran, Soica, Codruţa, Bojin, Florina   +17 more
core   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Climate change adaptation in arable land use, and impact on nitrogen load at catchment scale in northern agriculture

Agricultural and Food Science, 2013
Prolongation of the growing season due to a warming climate could represent new opportunities for northern agriculture. Climatic and biotic constraints may challenge future crop production.
Katri Rankinen, Pirjo Peltonen-Sainio, Kirsti Granlund, Hannu Ojanen, Mikko Laapas, Kaija Hakala, Kalle Sippel, Juha Helenius, Martin Forsius   +8 more
doaj  

Porkkanalajikkeiden varastointikoe 1995

, 1997
vokMyynti: MTT puutarhatuotannon tutkimuslaitos. Hinta: 5 raporttia yht.
Suojala, Terhi
core  

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source