Results 31 to 40 of about 4,749 (196)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Deri enfeksiyonlarının anksiyete üzerine etkisinin araştırılması: Türk güreşçileri üzerinde bir çalışma

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2017
Bu çalışmanın amacı Türk güreşçilerinde deri enfeksiyonlarının sıklığını incelemek ve güreşçilerde deri enfeksiyonlarının anksiyeteye neden olup olmadığını araştırmak.
Ömer Kaynar, Mikail Yılmaz, Mahmut Akyüz   +2 more
doaj   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

The applicability of percutaneous nephrolithotomy in provincial state hospitals: the experience of the State Hospital of Mu in first 100 cases

Urology Research and Practice, 2019
Objective: We aimed to evaluate if percutaneous nephrolithotomy (PCN) operation, which is commonly and successfully performed in current practice, could be performed in provincial state hospitals of Turkey.
Mehmet Bilgehan Yüksel, Aytan Kar, Murat Çiloğlu   +2 more
doaj   +2 more sources

Üniversite Öğrencilerinin Yaşadıkları Sosyo-Ekonomik Sorunlar Üzerine Bir İnceleme

Üniversite Araştırmaları Dergisi, 2021
Bu çalışmanın amacı üniversite öğrencilerinin yaşadıkları sosyo-ekonomik sorunların boyutu ve sosyal yardımlara erişim biçiminin tespit edilmesidir. Çalışmada nicel araştırma yöntemlerinden tarama modeli kullanılmıştır.
Hüseyin Doğan, Gökçe Akçalı
doaj   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Optimization of Non-Linear Problems Using Salp Swarm Algorithm and Solving the Energy Efficiency Problem of Buildings with Salp Swarm Algorithm-based Multi-Layer Perceptron Algorithm

Electrica
The aim of this paper is to evaluate the optimization capabilities of the salp swarm algorithm (SSA), a metaheuristic algorithm capable of addressing contemporary global challenges.
Erdal Eker, Şeymanur Atar, Fatih Şevgin, İhsan Tuğal   +3 more
doaj   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Spor Eğitimi Alan Üniversite Öğrencilerinde Teknoloji Bağımlılığı ve Spora Yönelik Tutumun İncelenmesi

Sportif Bakış Spor ve Eğitim Bilimleri Dergisi
Bu çalışmanın amacı, üniversite öğrencilerinin dijital teknoloji kullanım alışkanlıklarının demografik değişkenlere göre nasıl farklılaştığını belirlemek ve teknoloji kullanımı ile spora yönelik tutumlar arasındaki ilişkiyi incelemektir.
Muhammet Bas, Gurkan Tanoglu, Atakan Aksu   +2 more
doaj   +1 more source