Results 111 to 120 of about 133,349 (299)

Transmembrane Mucin-1 Facilitates Oral Microbial Colonization in Oral Cancer

open access: yesOral
Mucins are a family of heavily glycosylated proteins that form the main organic component of the oral mucosal barrier complex. Transmembrane mucin 1 (tMUC1) is anchored at the superficial epithelial surface to provide a protective function.
Bina Kashyap, Arja M. Kullaa
doaj   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang   +10 more
wiley   +1 more source

Friend and foe: factors influencing the movement of the bacterium Helicobacter pylori along the parasitism-mutualism continuum. [PDF]

open access: yes, 2014
Understanding the transition of bacterial species from commensal to pathogen, or vice versa, is a key application of evolutionary theory to preventative medicine.
Koskella, Britt, Lin, Derek
core   +1 more source

Identification and Investigation of Mucin 1‐Mediated Kidney Disease

open access: yesThe FASEB Journal, 2015
Establishing a causal link between genomic variation and pathology is the foundation of the successful application of genomics to clinical medicine. Whole genome sequencing (WGS) increases the resolution with which we can investigate the genome, but this increased resolution leads to an increase in the number of potentially damaging or disease causing ...
Bryce Schuler   +6 more
openaire   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

open access: yesAdvanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai   +6 more
wiley   +1 more source

Histopathological and ultrastructural evaluations of giant African snail (Achatina fulica) mucin and alginate hydrogel on cutaneous wound healing in rats

open access: yesOpen Veterinary Journal
Background: Wound healing is a complex biological process that involves inflammation, cellular proliferation, and tissue remodeling. Efficient and prompt wound repair is critical for infection prevention and tissue integrity restoration.
Mohammad Reza Salahi   +4 more
doaj   +1 more source

Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. [PDF]

open access: yes, 2012
OBJECTIVE: The intestinal inflammation observed in patients with ankylosing spondylitis (AS) is characterized by an overexpression of interleukin-23 (IL-23). IL-23 is known to regulate IL-22 production through lamina propria NKp44+ natural killer (NK)
Accardo Palumbo A   +9 more
core   +1 more source

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

open access: yesAdvanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi   +6 more
wiley   +1 more source

Follicular Adenoma with Extensive Extracellular Mucin Deposition: Report on Two Cases

open access: yesClinical Medicine Insights: Case Reports, 2012
We report two cases of follicular adenoma of the thyroid with extensive extracellular mucin deposition. Fine needle aspiration in Case 1 showed singly discohesive polygonal cells in a granular mucinous background.
Na Rae Kim   +5 more
doaj   +1 more source

Nanowire Biosensors for Label-Free, Real-Time, Ultrasensitive Protein Detection [PDF]

open access: yes, 2013
Sensitive and quantitative analysis of proteins is central to disease diagnosis, drug screening, and proteomic studies. Among recent research advances exploiting new nanomaterials for biomolecule analysis, silicon nanowires (SiNWs), which are configured ...
Lieber, Charles M., Zheng, Gengfeng
core   +1 more source

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