Results 201 to 210 of about 107,445,010 (245)

Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae

iMeta, EarlyView.
Transient exposure to ampicillin results in restructuring of microbiota to favor oxygen‐tolerant bacteria, whereas osmotic laxative perturbation preserves Bacteriodota. Ampicillin‐ but not laxative‐exposed environment favors establishment of rmpA phase variants that lost hypermucoviscosity but short‐chain fatty acids present in the laxative‐exposed gut
Carey Lim, Jialing Zheng, Guoxiang Cheam, Melvin Yong, Hanrong Chen, Andrew Ting, Yahua Chen, Qingqing Wang, Niranjan Nagarajan, Yunn‐Hwen Gan   +9 more
wiley   +1 more source

Gut virome orchestrates nitrogen partitioning between the host and microbiome

iMeta, EarlyView.
Under normal protein intake, lytic phages promote bacterial turnover, releasing microbial nitrogen that can be assimilated by the host and thereby revealing phage‐mediated lysis as a potential pathway for host nutrient acquisition. Under protein restriction, however, phages shift toward a lysogenic strategy, reducing bacterial death and microbial ...
Shujie Xu, Xianglin Fei, Fengqing Lin, Wenzi Wu, Jiachen Zhuang, Qiufen Mo, Xiuan Zhan, Aikun Fu   +7 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

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Role of Mucin‐1 in Carcinomas

The FASEB Journal, 2020
Mucin 1 (MUC1) is a large, heavy O‐glycosylated mucin glycoprotein with a molecular weight of 250 to 500 kDa, depending on the level of glycosylation, and extends 200–500 nm from the cell surface. MUC1 spans the cell membrane at the apical surface of normal simple epithelia and the surfaces of some ...
Tina Link, Olivia Caruso, Abhishek Kona, Allison Lu, Zara Saberi, Tara Shabazaz, Varun Vijay   +6 more
openaire   +1 more source

Advances in the Applications of Mucin 1 in Cancer Therapy

Journal of Biomedical Nanotechnology, 2023
Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that is mainly expressed in epithelial cells and some hematopoietic cells. Mucin 1 was overexpressed in many cancer tissues compared to normal tissue with a lower degree of glycosylation.
Ben Yang, Hanyue Li, Fei Wang, Changjun Zuo, Yicheng Qi, Tiantian Song, Sipeng Sun, Rongguan Kou, Anping Wang, Hui Wang, Mengqi Shi, Wenjing Yu, Yubing Wang, Zhiqin Gao   +13 more
openaire   +1 more source

Role of Mucin 1 and Glycodelin A in recurrent implantation failure

Fertility and Sterility, 2015
To evaluate and compare the levels of Mucin 1 (MUC-1) and Glycodelin A (GdA) in precisely timed endometrial biopsies and blood samples taken from women with recurrent implantation failure, and women with proven fertility, in a control group.Molecular studies in human blood and tissue.University hospital.Women with recurrent implantation failure and ...
Ercan Bastu, Mehmet F. Mutlu, Cenk Yasa, Ozlem Dural, Asli Nehir Aytan, Cem Celik, Faruk Buyru, John Yeh   +7 more
openaire   +2 more sources

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

Current Cancer Drug Targets, 2022
Abstract:Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC.
Lekshmi R. Nath, Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, Reshma Ravindran Nair   +4 more
openaire   +2 more sources

Update on Mucin-1 immunotherapy in cancer: a clinical perspective

Expert Opinion on Biological Therapy, 2015
Mucin 1 (MUC1) is particularly well suited as a cancer immunotherapy target due to the elevated protein expression and aberrant forms associated with malignancy. A variety of therapeutic strategies have been explored, including antibodies intended to induce cancer cell destruction, and vaccinations with peptides, tumor extracts, and gene expression ...
Gareth, Rivalland, Bruce, Loveland, Paul, Mitchell   +2 more
openaire   +2 more sources

Cancer specific Mucin‐1 glycoforms are expressed on multiple myeloma

British Journal of Haematology, 2006
SummaryPresent therapies cannot cure the large majority of patients with multiple myeloma (MM) and therefore new treatment strategies are imperative. This study analysed the different glycosylation profiles of Mucin‐1 (MUC1) on MM and acute myeloid leukaemia (AML) cells using a series of anti‐MUC1 antibodies.
Cloosen, S., Gratama, J., Leeuwen, E.B.M. van, Senden-Gijsbers, B.L.M.G., Oving, E.B.H., Mensdorff-Pouilly, S., Tarp, Mads Peter Agervig, Clausen, Ulla Marie Mandel, Clausen, H., Germeraad, W.T.V., Bos, G.M.J.   +10 more
openaire   +2 more sources

Aptamer-Gated Ion Channel for Ultrasensitive Mucin 1 Detection

Analytical Chemistry, 2021
Detection of cancer markers is important for early diagnosis and timely treatment of cancer. In this study, we fabricated a tailorable gold nanofilm-anodized aluminum oxide (Au-AAO) ion channel through nanoparticle self-assembly and proposed a highly sensitive and selective Mucin 1 (MUC1) detection method.
Mengying Pan, Jiarong Cai, Si Li, Liguang Xu, Wei Ma, Chuanlai Xu, Hua Kuang   +6 more
openaire   +2 more sources