Results 51 to 60 of about 107,445,010 (245)

Mucin 1 Regulates Cox-2 Gene in Pancreatic Cancer [PDF]

Pancreas, 2015
Eighty percent of pancreatic ductal adenocarcinomas (PDAs) overexpress mucin 1 (MUC1), a transmembrane mucin glycoprotein. MUC1(high) PDA patients also express high levels of cyclooxygenase 2 (COX-2) and show poor prognosis. The cytoplasmic tail of MUC1 (MUC1-CT) partakes in oncogenic signaling, resulting in accelerated cancer progression.
Nath, Sritama, Roy, Lopamudra Das, Grover, Priyanka, Rao, Shanti, Mukherjee, Pinku   +4 more
openaire   +2 more sources

An Enzymatic Toolkit for Selective Proteolysis, Detection, and Visualization of Mucin-Domain Glycoproteins [PDF]

, 2020
Densely O-glycosylated mucin domains are found in a broad range of cell surface and secreted proteins, where they play key physiological roles. In addition, alterations in mucin expression and glycosylation are common in a variety of human diseases, such
Carolyn, Bertozzi, D. Judy, Shon, Stacy, Malaker, Kayvon, Pedram, Venkatesh, Krishnan, Oliver, Dorigo, Emily, Yang   +6 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation [PDF]

, 2015
The authors acknowledge the support of the Biotechnology and Biological Sciences Research Council (BBSRC), this research was partly funded by the BBSRC Institute Strategic Programme for The Gut Health and Food Safety (BB/J004529/1) and by the BB/L008602 ...
Vos, W.M., de, Hardy-Goddard, Jemma, Crost, Emmanuelle H., de Vos, Willem M., Gall, G., Le, Taylor, Garry L., Walshaw, J., Tailford, L.E., Crost, E.H., Taylor, G.L., Juge, N., Owen, C.D., Tailford, Louise E., Owen, C. David, Le Gall, Gwenaelle, Hardy-Goddard, J., Juge, Nathalie, Walshaw, John, Taylor, Garry L.; id_orcid   +18 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The isolation, purification, tissue localization and identification of a glycoprotein found in the crude mucus gel of patients with carcinoma of the stomach [PDF]

, 2008
Includes bibliographical references (leaves 101-138).The thin layer of crude mucus lining the human gastric mucosa protects the delicate gastric epithelium from the high shear forces associated with digestion. Gastric mucus is composed largely of water (>
Nthato, Chirwa
core   +1 more source

Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodies [version 2; referees: 2 approved]

F1000Research, 2016
Polymorphisms in the T cell (or transmembrane) immunoglobulin and mucin domain 1 (TIM-1) gene, particularly in the mucin domain, have been associated with atopy and allergic diseases in mice and human. Genetic- and antibody-mediated studies revealed that
Binh Phong, Lawrence P. Kane
doaj   +1 more source

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Gastric remnant carcinoma : histochemical and immunohistochemical profile [PDF]

, 2004
Includes bibliographical references (leaves 52-65).Gastric remnant carcinoma (GRC) is a gastric cancer that develops in gastric remnant more than five years after resection for benign disease. GRC comprises 1 %-9% of all gastric cancers.
Elazzabi, Tawfik
core   +1 more source