Results 61 to 70 of about 29,844,443 (188)

Induction of Colonic Aberrant Crypts in Mice by Feeding Apparent N-Nitroso Compounds Derived From Hot Dogs [PDF]

, 2012
Nitrite-preserved meats (e.g., hot dogs) may help cause colon cancer because they contain N-nitroso compounds. We tested whether purified hot-dog-derived total apparent N-nitroso compounds (ANC) could induce colonic aberrant crypts, which are putative ...
Mirvish, Sidney S., Lisowyj, Michal P, Davis, Michael E, Wisecarver, James L., Zhou, Lin, Gulizia, James M, Mirvish, Sidney S, Wisecarver, James L, Naud, Nathalie, Davis, Michael E., Shostrom, Valerie K, Corpet, Denis E., Lisowyj, Michal P.   +12 more
core   +1 more source

Probing Aberrantly Glycosylated Mucin 1 in Breast Cancer Extracellular Vesicles

, 2023
Aberrantly glycosylated mucin 1 is a critical prognostic biomarker in breast epithelial cancers. Hypoglycosylated mucin 1 coats the surface of the cancer cells, where O-glycans are predominantly linked via an N-acetylgalactosamine moiety (GalNAc). Cancer
Chrysafis Andreou (1890958), Suchetan Pal (1628932), Debashish Paul (9047466), Saroj Saroj (13749336), Akbar Ali (148512), Tatini Rakshit (817189)   +5 more
core   +1 more source

A Monoclonal Antibody Against the Oncogenic Mucin 1 Cytoplasmic Domain [PDF]

Hybridoma, 2011
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed in diverse human carcinomas and certain hematologic malignancies. The transmembrane MUC1-C subunit confers tumorigenicity and is a target for anti-cancer drug development. In this regard, the MUC1-C cytoplasmic domain interacts with multiple effectors that have been linked to ...
Govind, Panchamoorthy, Hala, Rehan, Akriti, Kharbanda, Rehan, Ahmad, Donald, Kufe   +4 more
openaire   +2 more sources

Thermal characterisation of PEGylated mucin [PDF]

, 2010
ObjectiveTo investigate the characteristics of PEGylated mucin and its potential usage.MethodsMucin was extracted from giant African land snails and PEGylated mucin was prepared with different ratios of PEG 2000-Mwt and mucin (1 : 1, 0 : 1, 2 : 1, 1 : 3 ...
Attama, AA, Adikwu, MU, MA Momoh, AA Attama, KC Ofokansi, MU Adikwu, CE Ibezim, Momoh, MA, Ibezim, CE, Ofokansi, KC   +9 more
core   +1 more source

Regulation of mucin 1 expression and its relationship with oral diseases

Archives of Oral Biology, 2020
The aim of this study is to describe the polymorphic mucin 1 (MUC1), and to provide an overview of the known complex and multiple functions of MUC1 in normal oral mucosa and oral mucosal lesions in compromised situations as well as exploring the challenges associated with the heterogeneous nature of MUC1.
Kashyap, Bina, Kullaa, Arja M
openaire   +3 more sources

Immunobiology of human mucin 1 in a preclinical ovarian tumor model [PDF]

Oncogene, 2012
Epithelial ovarian cancer is an aggressive malignancy, with a low 5-year median survival. Continued improvement on the development of more effective therapies depends in part on the availability of adequate preclinical models for in vivo testing of treatment efficacy.
R A, Budiu, E, Elishaev, J, Brozick, M, Lee, R P, Edwards, P, Kalinski, A M, Vlad   +6 more
openaire   +2 more sources

Mucin-1 is expressed on dendritic cells, both in vitro and in vivo [PDF]

International Immunology, 2004
Dendritic cells (DCs) are the best professional antigen-presenting cells to stimulate cytotoxic as well as T helper cells and are therefore appropriate candidates for establishing immunotherapy. The concept of our vaccination program is to introduce the tumor-associated antigen mucin-1 (MUC1) into DCs.
Silvie, Cloosen, Marco, Thio, Ariane, Vanclée, Ellen B M, van Leeuwen, Birgit L M G, Senden-Gijsbers, Ellis B H, Oving, Wilfred T V, Germeraad, Gerard M J, Bos   +7 more
openaire   +2 more sources

The inhibition of HIV-1 activity by crude mucus and purified mucin (mucous glycoproteins) from saliva, breast milk and the cervical tract of normal subjects, HIV positive individuals and patients with HIV-AIDS [PDF]

, 2007
Includes bibliographical references (leaves 140-161).Human saliva, breast milk and cervical secretions contain several non-immunological components including mucins (mucous glycoproteins), which protect the gastrointesinal and female reproductive tracts ...
Habte, Habtom Haileselassie
core   +1 more source

Mucin glycan foraging in the human gut microbiome

Frontiers in Genetics, 2015
The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key role in shaping the structure-function of the microbiota. In particular, some gut bacteria have the ability to forage on glycans provided by the mucus layer
Louise eTailford, Emmanuelle eCrost, Devon eKavanaugh, Nathalie eJuge   +3 more
doaj   +1 more source

Effect of dietary fiber and threonine content on intestinal barrier function in pigs challenged with either systemic E. coli lipopolysaccharide or enteric Salmonella Typhimurium

Journal of Animal Science and Biotechnology, 2020
Background The independent and interactive effects of dietary fiber (DF) and threonine (Thr) were investigated in growing pigs challenged with either systemic E.
Michael O. Wellington, Kimberley Hamonic, Jack E. C. Krone, John K. Htoo, Andrew G. Van Kessel, Daniel A. Columbus   +5 more
doaj   +1 more source