Results 151 to 160 of about 116,093,450 (283)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Mucin-rich and mucin-poor colorectal signet ring cell carcinoma: clinicopathological characteristics and prognostic significance

Background Recent findings suggest that colorectal signet ring cell carcinoma (SRCC) can be categorized into two histological types—mucin-rich and mucin-poor—based on the quantity of extracellular mucin, but the prognostic value and the molecular ...
Mian Chen, Rui Zhong, Yunxing Shi, Liang Huang, Hailing Liu, Fujin Ye, Minyi He, Donglong Xu, Zhanzhen Liu   +8 more
core   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Extending Small‐Molecule Aptamer Discovery Principles to Protein Targets: Selection and Characterization of Green Fluorescent Protein Aptamers

Angewandte Chemie, EarlyView.
Protein‐binding aptamers remain poorly understood compared to their small‐molecule counterparts. Using green fluorescent protein (GFP) variants as a tractable model system, we show how subtle changes in protein surface composition and divalent metal ions reshape aptamer selection, specificity, and binding.
Stefen Stangherlin, Nathan Wong, Logan Fanning, Kate Kim, Peter Kim, Iffat Tabassum, Songyang Miao, Rui Huang, Juewen Liu   +8 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Mucin 1 downregulation decreases the anti-tumor effects of melanoma vaccine. [PDF]

Ann Transl Med, 2022
Shi F, Xue R, Xu H, Mei F, Bao X, Dou J, Zhao F.   +6 more
europepmc   +1 more source

Mucin 1 (MUC1; CD227) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Erweiterung der Peptidligation auf Saure pH‐Bereiche und Schnittstellen mit Glykosylierten und Phosphorylierten Aminosäuren

Angewandte Chemie, EarlyView.
Ein pyridinhaltiges Ligationsauxiliar beseitigt einen wesentlichen Engpass der Peptidligationschemie. Der für die Ligation nutzbare pH‐Bereich von 2,0–7,5 hilft, Epimerisierung zu vermeiden. Die native chemische Ligation (NCL) verläuft an praktisch jeder Ligationsstelle, einschließlich Reaktionen an β‐verzweigten sowie O‑glykosylierten oder O ...
Sebastian Trunschke, Antonia Feida, Hendrik Hanebrink, Arseniy Galashov, Alina Herfort, Oliver Seitz   +5 more
wiley   +1 more source

Mucin 1 (MUC1; CD227) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Effects of enhancer of zeste homolog 2 and mucin 1 expressions on treatment response in breast cancer. [PDF]

Rev Assoc Med Bras (1992), 2023
Yetişir AE, Paydaş S, Büyükşimşek M, Oğul A, Yaprak Ö, Zorludemir S, Ergin M, Kolsuz İ, Kidi MM.   +8 more
europepmc   +1 more source