Results 191 to 200 of about 133,349 (299)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Mucin 1 promotes salivary gland cancer cell proliferation and metastasis by regulating the epidermal growth factor receptor signaling pathway. [PDF]

J Dent Sci, 2023
Lu H, Xu WL, Wu YF, Yang WJ, Liu SW.
europepmc   +1 more source

Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity

Advanced NanoBiomed Research, EarlyView.
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang   +4 more
wiley   +1 more source

The network map of mucin 1 mediated signaling in cancer progression and immune modulation. [PDF]

Discov Oncol
Palollathil A, Dagamajalu S, Ahmed M, Vijayakumar M, Prasad TSK, Raju R.   +5 more
europepmc   +1 more source

Mucin 1 aggravates synovitis and joint damage of rheumatoid arthritis by regulating inflammation and aggression of fibroblast-like synoviocytes. [PDF]

Bone Joint Res, 2022
Zou Y, Zhang X, Liang J, Peng L, Qin J, Zhou F, Liu T, Dai L.   +7 more
europepmc   +1 more source

MUCIN 1 confers inflammatory memory of tyrosine kinase inhibitor resistance in non-small cell lung cancer. [PDF]

Signal Transduct Target Ther
Takamori S, Haratake N, Bhattacharya A, Kikutake C, Ozawa H, Shigeta K, Nakashoji A, Isozaki H, Shimokawa M, Suyama M, Hashinokuchi A, Takada K, Toyokawa G, Yamada Y, Takenaka T, Taguchi K, Yamaguchi M, Yoshizumi T, Hata AN, Kufe D.   +19 more
europepmc   +1 more source

Combined Expression of HGFR with Her2/neu, EGFR, IGF1R, Mucin-1 and Integrin α2β1 Is Associated with Aggressive Epithelial Ovarian Cancer. [PDF]

Biomedicines, 2022
Czogalla B, Dötzer K, Sigrüner N, von Koch FE, Brambs CE, Anthuber S, Frangini S, Burges A, Werner J, Mahner S, Mayer B.   +10 more
europepmc   +1 more source

Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice. [PDF]

Nat Commun
Li Z, Gu R, Liu D, Zhang Y, Qin Y, Li X, Qiao Y, Li Z, Guo J, Wang J, Meng H, Peng L.   +11 more
europepmc   +1 more source

Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study. [PDF]

Cancer Cell Int, 2022
Vafaei R, Samadi M, Hosseinzadeh A, Barzaman K, Esmailinejad M, Khaki Z, Farahmand L.   +6 more
europepmc   +1 more source

Radium Speciation in Simulated Digestive Biofluids: Insights from Electrospray Ionization Mass Spectrometry and Thermodynamic Modeling

Analysis &Sensing, EarlyView.
Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann, Tim Schmalz, Tobias Weissenborn, Felix Stäger, Beate Riebe, Clemens Walther   +5 more
wiley   +1 more source