Results 231 to 240 of about 116,093,450 (283)

Gut microbiome seasonality is associated with dietary plasticity and coexistence in three sympatric Pamir ungulates

iMetaOmics, EarlyView.
This graphical abstract outlines a multi‐omics framework investigating the seasonal dietary composition and gut microbial communities of three coexisting ungulate species inhabiting the extreme high‐altitude Pamir Plateau (Ovis ammon polii, Capra sibirica, and Pseudois nayaur). By integrating dietary DNA metabarcoding, 16S rRNA gene sequencing, shotgun
Dilala Tuoliu, Lijiao Zhang, Muyang Wang, Wenxuan Xu, Kathreen Ruckstuhl, António Alves da Silva, Joana Alves, Hongchen Jiang, Weikang Yang   +8 more
wiley   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Comprehensive Performance Verification of the Mindray MN2880 System in Detecting Respiratory Virus Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
This study verified the analytical performance of the fully automated Mindray MN2880 system for the simultaneous detection of SARS‐CoV‐2, influenza A/B viruses, and RSV in 2852 oropharyngeal swab specimens, following CNAS‐GL039:2019, CNAS‐GL037:2019, and ISO 15189:2022 guidelines.
Jinliang Chen, Lianying Zeng, Hao Huang, Peisong Chen   +3 more
wiley   +1 more source

Image Quality of 1.5 T MRI Using Dual‐Type Deep Learning Reconstruction for Pancreatic Cystic Lesions: An Exploratory Comparison With Conventional 3 T MRI Without Deep Learning Reconstruction

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Dual‐type deep learning reconstruction (DLR) may improve the pancreatic MRI image quality; however, the effects of different DLR strengths at 1.5 T compared with the conventional 1.5 T and 3 T MRI without DLR remain unclear. Purpose To evaluate the image quality of 1.5 T MRI reconstructed with different DLR strengths for pancreatic ...
Masaki Tsuda, Taiki Nozaki, Koji Sumi, Minobu Kamo, Ippei Ozaki, Fumio Morimura, Eugene Nishi, Yohsuke Suyama, Hiroaki Sugiura, Hiromi Edo   +9 more
wiley   +1 more source

How Thunderstorms Are Changing in Mexico: Trends and Characteristics

International Journal of Climatology, EarlyView.
Thunderstorm days in Mexico have increased significantly since 1992, with pronounced regional and seasonal contrasts. Increasing moisture emerges as the most spatially coherent environmental signal. At the same time, enhanced instability characterizes northeastern and central Mexico, revealing distinct regional controls on thunderstorm activity and ...
José Francisco León‐Cruz, Alejandro Jaramillo‐Moreno, Karla Pereyra‐Castro, Christian Dominguez   +3 more
wiley   +1 more source