Results 81 to 90 of about 133,349 (299)

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Effect of dietary fiber and threonine content on intestinal barrier function in pigs challenged with either systemic E. coli lipopolysaccharide or enteric Salmonella Typhimurium

Journal of Animal Science and Biotechnology, 2020
Background The independent and interactive effects of dietary fiber (DF) and threonine (Thr) were investigated in growing pigs challenged with either systemic E.
Michael O. Wellington, Kimberley Hamonic, Jack E. C. Krone, John K. Htoo, Andrew G. Van Kessel, Daniel A. Columbus   +5 more
doaj   +1 more source

Clinicopathological characteristics of mucin phenotype and its relation to the malignant potential in early differentiated gastric adenocarcinoma

European Journal of Inflammation, 2021
Objectives Mucin phenotype is a tool to classify gastric cancer, but the relationship between mucin phenotype and its malignancy is still controversial.
Takanobu Akaishi, Tadashi Yoshizawa, Satoko Morohashi, Shintaro Goto, Takahiro Muroya, Harue Akasaka, Kenichi Hakamada, Hiroshi Kijima   +7 more
doaj   +1 more source

Mutations causing medullary cystic kidney disease type 1 (MCKD1) lie in a large VNTR in MUC1 missed by massively parallel sequencing [PDF]

, 2014
While genetic lesions responsible for some Mendelian disorders can be rapidly discovered through massively parallel sequencing (MPS) of whole genomes or exomes, not all diseases readily yield to such efforts.
Aird, Daniel, Alper, Seth L., Antignac, Corinne, Barešová, Veronika, Bleyer, Anthony J., Blumenstiel, Brendan, Cabili, Moran N., Cibulskis, Kristian, Daly, Mark J., Daza, Riza, DeFelice, Matthew, Gabriel, Stacey, Gat-Viks, Irit, Gnirke, Andreas, Green, Todd, Guttman, Mitchell, Handsaker, Robert E., Hart, P. Suzanne, Hůlková, Helena, Jaffe, David B., Kelliher, Edward, Kirby, Andrew, Kmoch, Stanislav, Lander, Eric S., Lindblad-Toh, Kerstin, Nusbaum, Chad, Parkin, Melissa, Perrin, Danielle, Pochet, Nathalie, Pollak, Martin R., Regev, Aviv, Robinson, James T., Rossin, Elizabeth, Scheinman, Steven J., Sigurdsson, Snaevar, Sougnez, Carrie, Sovová, Jana, Steelman, Scott, Stevens, Christine, Vylet’al, Petr, Xavier, Ramnik J., Ye, Chun, Zody, Michael C.   +42 more
core   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, EarlyView.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source

Mucin-Like Domain of Mucosal Addressin Cell Adhesion Molecule-1 Facilitates Integrin α4β7-Mediated Cell Adhesion Through Electrostatic Repulsion

Frontiers in Cell and Developmental Biology, 2020
The homing of lymphocytes from blood to gut-associated lymphoid tissue is regulated by interaction between integrin α4β7 with mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) expressed on the endothelium of high endothelial venules (HEVs ...
MengYa Yuan, YanRong Yang, Yue Li, Yue Li, ZhanJun Yan, ChangDong Lin, JianFeng Chen, JianFeng Chen   +7 more
doaj   +1 more source

Streptavidin Modified ZnO Film Bulk Acoustic Resonator for Detection of Tumor Marker Mucin 1 [PDF]

, 2016
A ZnO-based film bulk acoustic resonator has been fabricated using a magnetron sputtering technology, which was employed as a biosensor for detection of mucin 1.
Dan Zheng, Juan Xiong, Peng Guo, Shengfu Wang   +3 more
core   +1 more source

Immunobiology of human mucin 1 in a preclinical ovarian tumor model [PDF]

Oncogene, 2012
Epithelial ovarian cancer is an aggressive malignancy, with a low 5-year median survival. Continued improvement on the development of more effective therapies depends in part on the availability of adequate preclinical models for in vivo testing of treatment efficacy.
R A, Budiu, E, Elishaev, J, Brozick, M, Lee, R P, Edwards, P, Kalinski, A M, Vlad   +6 more
openaire   +2 more sources

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Expression von E-Cadherin, Beta-Catenin und Mucin-1 bei einherdigen im Vergleich zu mehrherdigen Mammakarzinomen [PDF]

, 2013
Hintergrund und Zielsetzung: Die aktuelle TNM-Klassifikation berücksichtigt bis dato nicht die tatsächliche Tumorlast bei mehrherdigen Mammakarzinomen. Neuere Daten weisen darauf hin, dass mehrherdige Karzinome im Vergleich zu einherdigen Karzinomen bei
Hirte, Eva
core