Results 251 to 260 of about 32,982 (330)

Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment

open access: yesSmall Science, Volume 5, Issue 4, April 2025.
Phagocytosis of “apoptotic tumor cells”, known as efferocytosis, accelerates the formation of an immunosuppressive microenvironment, leading to the detriment of tumor therapy. Blocking this process represents one of the novel approaches for treating tumors.
Gangxing Zhu   +9 more
wiley   +1 more source

Role of TP53 Mutations and EGFR Amplification in Risk Stratification of Early‐Stage EGFR‐Mutated Non‐Small Cell Lung Cancer With Immunohistochemistry as a Surrogate Marker

open access: yesThoracic Cancer, Volume 16, Issue 7, April 2025.
Specific TP53 mutations and epidermal growth factor receptor (EGFR) amplification are associated with worse prognosis in early‐stage EGFR‐mutated non‐small cell lung cancer (NSCLC). Immunohistochemistry (IHC) (p53, EGFR) correlates with genetic alterations, providing a practical surrogate marker for risk stratification.
Meejeong Kim   +4 more
wiley   +1 more source

A multicentre prospective single‐arm clinical trial to evaluate the treatment outcomes of prophylactic laparoscopic lateral pelvic lymph node dissection for advanced lower rectal cancer

open access: yesColorectal Disease, Volume 27, Issue 4, April 2025.
Abstract Aim There has been no prospective multicentre validation of the treatment outcomes of minimally invasive lateral pelvic lymph node dissection for lower rectal cancer; hence, this prospective study aimed to evaluate the treatment outcomes of prophylactic laparoscopic lateral pelvic lymph node dissection. Method Between May 2018 and August 2021,
Atsushi Hamabe   +19 more
wiley   +1 more source

Mutational Analysis of Bile Cell‐Free DNA in Primary Sclerosing Cholangitis: A Pilot Study

open access: yesLiver International, Volume 45, Issue 4, April 2025.
ABSTRACT Background Primary sclerosing cholangitis (PSC) is a chronic liver disease characterised by inflammation and fibrosis of the bile ducts, conferring an increased risk of cholangiocarcinoma (CCA). However, detecting CCA early in PSC patients remains challenging due to the limited sensitivity of conventional diagnostic methods, including imaging ...
Maria Arechederra   +25 more
wiley   +1 more source

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