Results 131 to 140 of about 642,073 (244)

Direct tumour–adipocyte contact / Stroma AReactive Invasion Front Area (TAC/SARIFA) predicts adverse outcome in colorectal cancer: a focused evidence synthesis and meta‐analysis

Histopathology, EarlyView.
TAC/SARIFA, defined by direct tumour–adipocyte contact at the invasion front, represents a reproducible, biologically meaningful H&E biomarker with consistent adverse prognostic associations in CRC. Aims Direct tumour‐adipocyte interaction at the invasion front, termed Stroma AReactive Invasion Front Areas (SARIFA), has recently emerged as a novel H&E ...
Nic G Reitsam, Bruno Märkl, Iris D Nagtegaal, Magali Svrcek   +3 more
wiley   +1 more source

Hypercellular Mucinous Carcinoma Resembling Invasive Cribriform Carcinoma and Hypocellular Mucinous Carcinoma of the Breast; A Rare Case with Unique Association

75-years-old Japanese woman developed a breast tumor with approximate size of 60 mm. The tumor consisted of two lesions. The main neoplasm was made up of invasive epithelial islands with cribriform pattern resembling invasive cribriform carcinoma ...
Yoshimi Iriguchi, Yuichiro Okubo, Hideki Mori, Takahiro Mase   +3 more
core   +1 more source

Long‐term outcome of high‐grade encapsulated papillary carcinoma of the breast: implications for staging and management

Histopathology, EarlyView.
In the original study by Rakha et al., the authors proposed that high‐grade EPC should be considered within an invasive framework regardless of hormone receptor status. In the present study, we adopted a more selective definition of EPC‐A, restricted to tumours showing more adverse features, including high‐grade morphology together with triple‐negative
Milena Stevanovic, Emad Rakha, Ian O. Ellis, Umberto Maccio, Bärbel Papassotiropoulos, Hisham Fansa, Lidija Stevanovic, Heike Frauchiger‐Heuer, Isabell Witzel, Zsuzsanna Varga   +9 more
wiley   +1 more source

Do Clinical and Immunohistochemical Findings of Pure Mucinous Breast Carcinoma Differ from Mixed Mucinous Breast Carcinoma ?

Mucinous carcinoma of the breast is a relatively rare histologic type with two subtypes : pure and mixed. It has a favourable prognosis with a low risk of axillary metastases.
Ciris, M, Erhan, Y, Zekioglu, O, Kapkac, M, Ozdemir, N, Makay, Ö   +5 more
core  

Prognostic significance of preoperative serum CEA in primary mucinous ovarian carcinoma: a retrospective cohort study

, 2018
Wei Lin, Dongyan Cao, Keng Shen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Purpose: The purpose of this ...
Shen K, Lin W, Cao D
core  

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Distinct Rb expression pattern in HPV‐associated neuroendocrine carcinomas of the uterine cervix

Histopathology, EarlyView.
Most uterine cervical neuroendocrine carcinoma (UCNEC) cases are HPV‐associated and are characterized by partial loss of Rb, p16 overexpression, and cyclin D1 negativity. A minority of UCNECs exhibit a distinct pattern, characterized by HPV negativity, retained Rb expression, focal p16 expression and cyclin D1 positivity.
Nobuko Yasutake, Misato Komamizu, Takeshi Iwasaki, Ryosuke Kuga, Tomomi Manako, Mikiko Hashisako, Rina Jiromaru, Tomoko Sho, Norihito Yuge, Kenzo Sonoda, Hideaki Yahata, Yoshinao Oda, Hidetaka Yamamoto   +12 more
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source