Results 261 to 270 of about 1,366,092 (327)

A quantitative tumor‐wide analysis of morphological heterogeneity of colorectal adenocarcinoma

open access: yesThe Journal of Pathology: Clinical Research, Volume 11, Issue 4, July 2025.
Abstract The intertumoral and intratumoral heterogeneity of colorectal adenocarcinoma (CRC) at the morphologic level is poorly understood. Previously, we identified morphological patterns associated with CRC molecular subtypes and their distinct molecular motifs. Here we aimed to evaluate the heterogeneity of these patterns across CRC.
Mihnea P Dragomir   +7 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
This study identifies a key signaling pathway involving the environmental sensor AhR and antimicrobial peptides, such as BD‐1, in the regulation of intestinal homeostasis. It highlights the role of BD‐1 in regulating gut microbiota and the intestinal immune response.
Manikandan Palrasu   +16 more
wiley   +1 more source

Nutritional benefits of pancreas‐sparing total duodenectomy for severe duodenal polyposis in patients with familial adenomatous polyposis

open access: yesAnnals of Gastroenterological Surgery, Volume 9, Issue 4, Page 822-829, July 2025.
The postoperative nutritional status of patients with familial adenomatous polyposis who underwent pancreas‐sparing total duodenectomy was better than that of patients who underwent pancreaticoduodenectomy. This study provides the first direct comparison of postoperative nutritional outcomes between patients with pancreas‐sparing total duodenectomy and
Ibuki Fujinuma   +11 more
wiley   +1 more source

Poorly differentiated mucinous carcinoma of the ascending colon complicated by bilateral ovarian mature cystic teratomas in a 17-year-old female patient: a case report. [PDF]

open access: yesSurg Case Rep
Shimogawa T   +11 more
europepmc   +1 more source

A Case of Mucinous Carcinoma of the Bilateral Breasts

open access: bronze, 2009
Minoru MORIWAKI   +7 more
openalex   +2 more sources

Tumor‐Infiltrating Lymphocytes in Breast and Female Genital Tract Cancers: Overlooked Potential and Unexplored Frontiers

open access: yesCancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Background The growing success of cancer immunotherapies has led to significant advances in oncology. However, despite these promising developments, cancer‐related mortality remains high for common cancer types such as breast and lower female genital tract cancers. Method Here, we synthesize recent findings on the prognostic relevance of tumor‐
Kristijan Skok   +3 more
wiley   +1 more source

Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition

open access: yesClinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Combination of Kras activation and Arid1a loss induces pancreatic cancer in mice. ARID1A deficiency enhances immune cell infiltration and lipid metabolism in pancreatic cancer. Fatty acid synthase (FASN) is a druggable target in ARID1A‐deficient pancreatic cancer.
Tzu‐Lei Kuo   +4 more
wiley   +1 more source

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