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Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies
Advanced Materials Interfaces, 2022 AbstractMucoadhesion is an extremely important field of adhesion science and the comprehensive understanding and modulation of mucoadhesion can lead to lifesaving materials and technologies. For instance, deadly cases of COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral adhesion and overproduction of mucus, which obstructs the airways ...
İlker Bayer
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Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale
Expert Opinion on Drug Delivery, 2011The benefits of mucoadhesive systems are related to the increased in situ residence and intimate contact of the delivery vehicle with the mucosa. The recent emergence of nanomedicine and the properties of nanoparticulate systems have created new challenges in understanding the nature and mechanisms of nanoscale mucoadhesion and in the development of ...
José, das Neves +3 more
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Quantitative evaluation of mucoadhesive polymers to compare the mucoadhesion
Journal of Pharmaceutical Investigation, 2016Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers ...
Cho-A Lee, Bo-Sik Kim, Cheong-Weon Cho
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Mucoadhesion and the Gastrointestinal Tract
Critical Reviews in Therapeutic Drug Carrier Systems, 2008The concept of mucoadhesion is one that has the potential to improve the highly variable residence times experienced by drugs and dosage forms at various sites in the gastrointestinal tract, and consequently, to reduce variability and improve efficacy. Intimate contact with the mucosa should enhance absorption or improve topical therapy.
Felipe J O, Varum +4 more
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A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids [PDF]
International Journal of Pharmaceutics, 2017 Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been ...
Michael T Cook +2 more
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Biomacromolecules, 2008
Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in aqueous solutions at pH < 6.5. It has been widely used for developing drug delivery systems because of its excellent mucoadhesive properties. Although many studies report on chitosan being mucoadhesive, the nature of interactions between chitosan and mucin remains ...
Ioannis A, Sogias +2 more
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Chitosan is a biocompatible and biodegradable amino polysaccharide, which is soluble in aqueous solutions at pH < 6.5. It has been widely used for developing drug delivery systems because of its excellent mucoadhesive properties. Although many studies report on chitosan being mucoadhesive, the nature of interactions between chitosan and mucin remains ...
Ioannis A, Sogias +2 more
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Mucoadhesion and Characterization of Mucoadhesive Properties
2014Mucoadhesive dosage forms may improve both in vitro and in vivo performance of products due to their propensity to enhance the retention of the dosage form at the site of application. The appropriate and reliable characterization of mucoadhesive systems is crucial to enable the identification of the appropriate formulations for in vivo use.
Yu, Tao, Andrews, Gavin, Jones, David
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Biochemical Society Transactions, 2003
The adhesive properties of certain types of biopolymer can be used to increase the residence time of orally or nasally administered drugs. A fuller understanding of the molecular processes underpinning such ‘mucoadhesive’ phenomena will help in the optimal design of delivery systems.
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The adhesive properties of certain types of biopolymer can be used to increase the residence time of orally or nasally administered drugs. A fuller understanding of the molecular processes underpinning such ‘mucoadhesive’ phenomena will help in the optimal design of delivery systems.
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Mucoadhesive Micropatterns for Enhanced Grip
2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007The main challenge in designing diagnostic devices able to move along the colon is their locomotion method. Manipulating friction with the colonic surface is a key requirement for their safe and atraumatic propagation. One possible solution is to generate friction by means of adhesive forces.
Dodou, D., del Campo, A., Arzt, E.
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Mucoadhesive Drug Delivery Systems
2009The uptake of drugs is often limited by the short contact time between the formulation and the absorption membrane and by a fast washout. Using mucoadhesive polymers, however, the residence time of the dosage form on the mucosa can be significantly increased.
Juliane, Hombach +1 more
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