Results 1 to 10 of about 1,420,172 (170)

Long-term safety and analgesic efficacy of buprenorphine buccal film in patients with moderate-to-severe chronic pain requiring around-the-clock opioids [PDF]

Journal of Pain Research, 2017
Martin Hale,1 Veronica Urdaneta,2 M Todd Kirby,3 Qinfang Xiang,4 Richard Rauck5 1Gold Coast Research, LLC, Plantation, FL, USA; 2Pharmacovigilance and Risk Management, 3Clinical Development, 4Biometrics, Endo Pharmaceuticals Inc., Malvern, PA, USA ...
Hale M, Urdaneta V, Kirby MT, Xiang Q, Rauck R   +4 more
doaj   +3 more sources

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation [PDF]

Pharmaceutics, 2021
The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and
Anroop B. Nair, Jigar Shah, Shery Jacob, Bandar E. Al-Dhubiab, Vimal Patel, Nagaraja Sreeharsha, Pottathil Shinu   +6 more
doaj   +2 more sources

Improved Transmucosal Delivery of Glimepiride via Unidirectional Release Buccal Film Loaded With Vitamin E TPGS-Based Nanocarrier [PDF]

Dose-Response, 2020
Glimepiride (GMD) is a hypoglycemic agent that has variation in bioavailability for its unexpected absorption. Glimepiride was formulated in a buccal film loaded with a nanobased formulation to enhance its absorption via buccal mucosa.
Tahani S. Basahih, Abdullah A. Alamoudi, Khalid M. El-Say, Nabil A. Alhakamy, Osama A. A. Ahmed   +4 more
doaj   +2 more sources

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Pharmaceutics, 2021
Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in ...
Shery Jacob, Anroop B. Nair, Sai H. S. Boddu, Bapi Gorain, Nagaraja Sreeharsha, Jigar Shah   +5 more
doaj   +3 more sources

Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model [PDF]

Saudi Pharmaceutical Journal, 2020
Administration of almotriptan as an oral therapy is largely limited because of poor aqueous solubility and rather low bioavailability. The aim of present investigation was to formulate oral mucoadhesive film of almotriptan to improve the drug delivery ...
Anroop B. Nair, Bandar E. Al-Dhubiab, Jigar Shah, Shery Jacob, Vismay Saraiya, Mahesh Attimarad, Nagaraja SreeHarsha, Sabah H. Akrawi, Tamer M. Shehata   +8 more
doaj   +2 more sources

Design, optimization and characterization of mucoadhesive buccal film as a novel delivery system for doxazosin mesylate [PDF]

Saudi Pharmaceutical Journal
Doxazosin mesylate is a selective α1-adrenergic receptor antagonist with low oral bioavailability due to poor aqueous solubility and extensive first-pass hepatic metabolism.
Nidhal Khazaal Maraie, Ali N. Wannas
doaj   +2 more sources

Physicochemical Properties of Pineapple Stem Fiber/Gellan Gum Biocomposite Films as a Potential Platform for Buccal Drug Delivery [PDF]

Journal of Functional Biomaterials
The physicochemical properties of buccal films are vital for evaluating their suitability for mucosal applications. By focusing on these properties, researchers can enhance the mechanical functionality and mucoadhesion of the films.
Tuty Fareyhynn Mohammed Fitri, Azlin Fazlina Osman, Eid Alosime, Sinar Arzuria Adnan, Nur Hidayah Ahmad Zaidi   +4 more
doaj   +2 more sources

Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery

e-Polymers, 2021
Design of experiments is used to optimize ratios between deproteinized natural rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent variables as moisture content, moisture uptake, and swelling index in simulated saliva 3 ...
Suksaeree Jirapornchai, Chaichawawut Benjarut, Srichan Muntira, Tanaboonsuthi Noppamon, Monton Chaowalit, Maneewattanapinyo Pattwat, Pichayakorn Wiwat   +6 more
doaj   +2 more sources

Development and Evaluation of Curcumin-Loaded Mucoadhesive Buccal Films Using Green Deep Eutectic Solvents via Design of Experiments [PDF]

Pharmaceutics
Background/Objectives: This study aimed to develop and formulation-design curcumin-loaded buccal films using a green deep eutectic solvent (DES) to improve drug solubility and support localized mucosal delivery, with the help of a Design of Experiments ...
Melike Zeynep Ünükür Sevim, Muhammet Davut Arpa, Kübra Kolci, Hande Sipahi, Neslihan Üstündağ Okur   +4 more
doaj   +2 more sources

Formulation and Characterization of Captopril-Loaded Chitosan Mucoadhesive Buccal Films with Different Permeation-Enhancing Components [PDF]

Pharmaceutics
Background/Objectives: The buccal mucosa offers a promising non-invasive route for systemic drug delivery, particularly for hydrophilic compounds like captopril (CAP), which exhibit low permeability and are subject to gastrointestinal instability and ...
Hala Rayya, Raghad Alsheikh, Dániel Nemes, Lajos Nagy, Géza Regdon, Ildikó Bácskay, Krisztián Pamlényi, Katalin Kristó   +7 more
doaj   +2 more sources