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Genetically Engineered Mucoadhesive Spider Silk
Biomacromolecules, 2018Mucoadhesion is defined as the adhesion of a material to the mucus gel covering the mucous membranes. The mechanisms controlling mucoadhesion include nonspecific electrostatic interactions and specific interactions between the materials and the mucins, the heavily glycosylated proteins that form the mucus gel.
Georgia Petrou +6 more
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Nanoscale technology of mucoadhesive interactions
Advanced Drug Delivery Reviews, 2004Nanoscale analysis may be used to design new types of mucoadhesive polymers. Understanding of the surface interactions between hydrophilic polymer surfaces and mucins can lead to improved adhesive bonding by hydrogen bonding. Alternatively, decoration of a mucoadhesive polymer surface with tethers of linear and block copolymers containing neutral or ...
Nicholas A, Peppas, Yanbin, Huang
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Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation
Drug Development and Industrial Pharmacy, 2004Different types of mucoadhesive polymers, intended for buccal tablet formulation, were investigated for their comparative mucoadhesive force, swelling behavior, residence time and surface pH. The selected polymers were carbopols (CP934, and CP940), polycarbophil (PC), sodium carboxymethyl cellulose (SCMC) and pectin representing the anionic type, while
Noha Adel, Nafee +3 more
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Vaginal mucoadhesive drug delivery systems
Drug Development and Industrial Pharmacy, 2011The vaginal mucosal cavity is a feasible, safe, very attractive site for drug delivery and highly dynamic with respect to absorption of drugs, their metabolism and their elimination. Compared with other mucosal application sites, the vagina has the following advantages as, a fall in the incidence and severity of gastrointestinal side effects, avoidance
Raphaela Regina, de Araújo Pereira +1 more
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Anhydrous thiomers: Strategy for enhanced mucoadhesion
European Journal of Pharmaceutics and Biopharmaceutics, 2018The aim of this study was to evaluate the impact of the absence of water during the synthesis of thiolated poly(acrylic acid) (PAA) on its mucoadhesive properties. Previously, thiolation of hydrophilic polymers was performed in aqueous media, where (poly)acrylates undergo a conformational transition to form an entangled network of polymer chains ...
Randi Angela, Baus +4 more
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Investigation of correlations between mucoadhesion and surface energy properties of mucoadhesives
Journal of Applied Polymer Science, 2006AbstractTo explore the correlations between mucoadhesion and the surface properties of mucoadhesive polymers, a series of polymer, poly[acrylic acid‐co‐poly(ethylene glycol) monomethylether monomethacrylate‐co‐dimethylaminoethyl methacrylate], poly(AA‐PEGMM‐DMEMA), was designed and synthesized as a model mucoadhesive in this study. Poly(AA‐PEGMM‐DMEMA)
Jun Xiang, Xiaoling Li
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Mucoadhesive Drug Delivery Systems
Drug Development and Industrial Pharmacy, 1993AbstractPharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because mucoadhesion could be a solution for bioavailability problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption site within the gastro-intestinal tract.This paper describes some aspects of ...
Ma Rosa Jiménez-castellanos +2 more
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Mucoadhesive Drug Delivery Systems
Drug Development and Industrial Pharmacy, 1997Mucoadhesion in drug delivery systems has recently gained interest among pharmaceutical scientists as a means of promoting dosage form residence time as well as improving intimacy of contact with various absorptive membranes of the biological system.
Alka Ahuja, Roop K. Khar, Javed Ali
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Mucoadhesive Vaginal Drug Delivery Systems
Recent Patents on Drug Delivery & Formulation, 2009Vaginal delivery is an important route of drug administration for both local and systemic diseases. The vaginal route has some advantages due to its large surface area, rich blood supply, avoidance of the first-pass effect, relatively high permeability to many drugs and self-insertion.
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