Results 51 to 60 of about 17,478 (246)

Assessment of Binary Agarose–Carbopol Buccal Gels for Mucoadhesive Drug Delivery: Ex Vivo and In Vivo Characterization

Molecules, 2022
Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that is converted to hydrocolloid gel in hot water with notable gel strength. Currently, its mucoadhesion properties have not been fully explored.
Muhammad Ali Syed, Sana Hanif, Noor ul Ain, Haroon Khalid Syed, Ameer Fawad Zahoor, Ikram Ullah Khan, Walaa A. Abualsunun, Abdulmajeed M. Jali, Safa H. Qahl, Muhammad H. Sultan, Osama A. Madkhali, Rayan A. Ahmed, Nasir Abbas, Amjad Hussain, Muhammad Abdul Qayyum, Muhammad Irfan   +15 more
doaj   +1 more source

Mucoadhesive Peptide-Catalase Self-Assembled Nano-Formulation for Effective Treatment of Mucosal Inflammatory Diseases. [PDF]

Adv Sci (Weinh)
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Li X, Ma Y, He D, Huang Y, Jiang Y, Zhao H, Ge S, Zhao R, Yuan H, Jiang W, Zhu W, Liu K, Zhang H, Liu Z.   +13 more
europepmc   +2 more sources

Programmable Pneumatic Actuator System for a Bioinspired Artificial Colon

Advanced Materials Technologies, EarlyView.
A modular soft robotic colon simulator driven by programmable pneumatic actuation is developed to mimic physiological and pathological‐like motility patterns of the large intestine. Finite element–guided design and distributed control enable anatomically realistic deformation for peristalsis, segmentation, and mass movements, supporting capsule ...
Andrew Bickerdike, Bo Tian, Xizheng Fang, Zepeng Wang, Yang Liu, Lucy Adams, Shyam Prasad   +6 more
wiley   +1 more source

Design and development of thermosensitive rectal in situ gel from Luffa acutangula fruits for the treatment of ulcerative colitis

Journal of Applied Pharmaceutical Research
Background: Luffa acutangula has good anti-inflammatory and antioxidant activity.  Ulcerative colitis has inflamed intestinal mucosal lining with frequent diarrhoea, mucosal, and bloody stools.
Swati P. Barangule, Avish D. Maru
doaj   +1 more source

An Effective Delivery System of Sitagliptin Using Optimized Mucoadhesive Nanoparticles

Applied Sciences, 2018
Sitagliptin (MK-0431), is a potent oral hypoglycemic drug that is used for treating type 2 diabetes mellitus. However, the short half-life of sitagliptin requires patients to take a high dose of 50 mg twice per day, and the fraction of sitagliptin ...
Afzal Haq Asif, Sree Harsha, Niranjan Hodalur Puttaswamy, Bandar E. Al-Dhubiab   +3 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Fabrication of Sublingual Alprazolam Wafers using Mucoadhesive Vigna mungo L. Seeds and Characterized with Texture Analyzer QTS-25

Journal of Pharmaceutical Research, 2023
Our primary goal of this work was to create and test a mucoadhesive lyophilized rapid dissolving sublingual wafer of Alprazolam using a natural mucoadhesive agent extracted from black gram (Vigna mungo L.) seeds.
Kazi Asraf ​ Ali, Riya Das, Sabyasachi Choudhuri   +2 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Development of mucoadhesive gelatin-based patches for aphthous ulcers [PDF]

, 2023
        Mucoadhesive patches demonstrate considerable promise for the administration of therapeutics targeting oral mucosal diseases.
Kriangkrai, Worawut, Lerdsrimongkol, Jiratchaya, Tiyaboonchai, Waree   +2 more
core   +1 more source

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source