Results 51 to 60 of about 5,563 (197)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Presentation of AIDS with Disseminated Cutaneous and Visceral Leishmaniasis in Iran

Case Reports in Infectious Diseases, 2015
Leishmaniasis is an infectious disease in form of visceral (VL), cutaneous (CL), and mucocutaneous (MCL) leishmaniasis. Immunocompromised patients have increased risk of Leishmania infection, especially in endemic areas for visceral leishmaniasis, where
Mohammadali Davarpanah, Masumeh Rassaei, Fatemeh Sari aslani   +2 more
doaj   +1 more source

Leishmania enriettii in guinea pig (Cavia porcellus) in southern Brazil [PDF]

Pesquisa Veterinária Brasileira
: Leishmaniasis is a parasitic disease with a worldwide distribution, transmitted to animals and humans through the blood meal of sand flies, caused by protozoa of the genus Leishmania.
Michelli L. de Souza, Fagner D. Fernandes, Gabriela Hartmann, Guilherme R. Cassanego, Rafael A. Fighera, Fernanda S.F. Vogel, Luís Antonio Sangioni   +6 more
doaj   +1 more source

Localised Leishmaniasis of Oral Mucosa: Report of an Unusual Clinicopathological Entity

Case Reports in Dentistry, 2014
The term leishmaniasis comprises of a group of diseases caused by different species of a protozoan called Leishmania. There are three main clinical forms of leishmaniasis: visceral leishmaniasis, cutaneous leishmaniasis, and mucocutaneous leishmaniasis ...
Deepak Passi, Sarang Sharma, Shubharanjan Dutta, Chandan Gupta   +3 more
doaj   +1 more source

Brief communication: Vitamin D serum levels in American tegumentary leishmaniasis from an endemic area in Northeast Brazil

Brazilian Journal of Infectious Diseases, 2023
Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of
Lorena Pinheiro Figueiredo, Thiago Cerqueira-Silva, Andréa Magalhães, Ednaldo Lima Lago, Marcus Miranda Lessa   +4 more
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Mucocutaneous leishmaniasis: A clinicopathologic classification

Journal of the American Academy of Dermatology, 1993
Leishmaniasis, a chronic parasitic disease transmitted by Phlebotomus sandflies, affects millions of patients. Mucocutaneous leishmaniasis caused by Leishmania brasiliensis is endemic in much of South America.Our purpose was to develop a system for staging mucocutaneous leishmaniasis on the basis of clinical, histopathologic, epidemiologic, and ...
O P, Sangueza, J M, Sangueza, M J, Stiller, P, Sangueza   +3 more
openaire   +2 more sources

Cutaneous Leishmaniasis in High‐Altitude: A Case Report From Nepal

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Leishmaniasis is a parasitic infection caused by Leishmania and spread by the bite of a sandfly, most commonly Phlebotomus. Among the three subtypes of Leishmaniasis, cutaneous leishmaniasis is the most common form. Visceral Leishmaniasis is common in Nepal whereas few cases of cutaneous leishmaniasis have been reported in migrant Nepalese ...
Eliz Aryal, Rohan Sapkota, Sunny Shrestha, Arika Baral, Santosh Sapkota, Mandish Prasad Phuyal   +5 more
wiley   +1 more source

Mucocutaneous leishmaniasis in Australia: A case report

Asian Pacific Journal of Tropical Medicine
Rationale: Australia is the only inhabited continent, which is not endemic to leishmaniasis. There are some published articles reporting cutaneous leishmaniasis in travellers, immigrants and refugees.
Anjali Abraham, Mini Jacob, Connor Wright, Belle Culhane   +3 more
doaj   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source