Results 41 to 50 of about 645,469 (305)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Clinical and immunopathological assessment of the oral mucosa in coeliac disease: a pilot study

BMC Oral Health
Background Coeliac disease (CD) is a lifelong immune-mediated systemic disease that develops in genetically predisposed subjects who show intolerance to gluten proteins.
Agnieszka Mania-Końsko, Zuzanna Ślebioda, Aleksandra Dańczak-Pazdrowska, Marzena Liliana Wyganowska   +3 more
doaj   +1 more source

Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans [PDF]

, 2009
Background: Mucosa-associated Escherichia coli are frequently found in the colonic mucosa of patients with colorectal adenocarcinoma, but rarely in healthy controls. Chronic mucosal E. coli infection has therefore been linked to colonic tumourigenesis. E.
Short, Abigail J., Abigail J Short, Maddocks, Oliver D. K., Donnenberg, Michael S., Abigail J. Short, David J Harrison, Oliver D K Maddocks, Bader, Scott, Scott Bader, Michael S. Donnenberg, Michael S Donnenberg, Maddocks, Oliver D.K., Oliver D. K. Maddocks, David J. Harrison, Harrison, David J., Harrison, David J.; id_orcid   +15 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Advances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems

Frontiers in Pharmacology
BackgroundRecurrent aphthous stomatitis (RAS), the most common inflammatory disease of the oral mucosa, has a complex etiology and diverse pathogenesis. To date, no curative treatment exists.
Xiangran Kong, Lin Fan, Dawei He, Lin Wang, Jiang Sun   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

In Vitro Study of Temperature Changes in Pulp Chamber During Root Planing Procedure Using Er:YAG Laser

Folia Medica, 2016
Aim: To assess temperature changes at specified time intervals during Er:YAG laser scaling and root planing of surfaces with dental calculus.
Yaneva Blagovesta K., Zagorchev Plamen I., Firkova Elena I., Glavinkov Ivan T.   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Photodynamic therapy in non-surgical treatment of periodontitis

Scientific Reports
Periodontitis is a chronic inflammation disease that, apart from caries, remains the main cause of tooth loss, that lead to a deterioration of the quality of life.
Adrian Maj, Aida Kusiak, Katarzyna Garbacz, Dominika Cichońska, Dariusz Świetlik   +4 more
doaj   +1 more source

Standing Guard at the Mucosa [PDF]

Immunity, 2011
Most successful vaccines elicit antibodies that protect against infection. In this issue of Immunity, Bomsel et al. (2011) show in the rhesus macaque model that vaccine-induced mucosal antibodies, rather than circulating neutralizing antibodies, may be critical components for protective immunity against HIV-1.
openaire   +2 more sources