Results 11 to 20 of about 70,682 (209)

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]

, 2016
Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S., Fanale, Michelle A., Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Kaseb, Ahmed O., Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Park, Haeseong, Patel, Shreyaskumar, Piha-Paul, Sarina A., Subbiah, Vivek, Tsimberidou, Apostolia M., Velez-Bravo, Vivianne M M., Wheler, Jennifer J., Zinner, Ralph G.   +17 more
core   +5 more sources

Oral mucositis: the hidden side of cancer therapy

Journal of Experimental & Clinical Cancer Research, 2020
Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments.
Claudio Pulito, Antonio Cristaudo, Caterina La Porta, Stefano Zapperi, Giovanni Blandino, Aldo Morrone, Sabrina Strano   +6 more
doaj   +1 more source

Actual duration of patient-reported mucositis: Far longer than 2 to 4 weeks and may be avoidable altogether [PDF]

Korean Journal of Clinical Oncology, 2016
The impression that oral mucositis is a brief 14–28 day-consequence of chemoradiation is misguided. Clinically significant patient-reported oral mucositis may last 46 to 102 days depending on the treatment schedule and the modality used.
Ricky Wayne McCullough
doaj   +1 more source

Mucosal Chemokines [PDF]

Journal of Interferon & Cytokine Research, 2017
Several chemokines have important functions in mucosal immunity. While there are many chemokines, 4 of them (CCL25, CCL28, CXCL14, and CXCL17) are especially important in mucosal immunity because they are homeostatically expressed in mucosal tissues. Of these, only CCL25 and CCL28 have been widely recognized as mucosal chemokines.
Hernández-Ruiz, Marcela, Zlotnik, Albert   +1 more
openaire   +4 more sources

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]

, 2017
Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence, Hsieh, Andrew C, Kim, Won, Lin, Amy M, Louttit, Mirela, Ryan, Charles J, Wei, Xiao X   +6 more
core   +1 more source

Interventions for preventing oral mucositis for patients with cancer receiving treatment [PDF]

, 2003
Background: Treatment of cancer with chemotherapy is becoming increasingly more effective but is associated with short and long-term side effects. Oral side effects remain a major source of illness despite the use of a variety of agents to prevent them ...
Bryan, Gemma, Clarkson, Jan E., Furness, Susan, Glenny, Anne-Marie, Khalid, Tasneem, Littlewood, Anne, McCabe, Martin G., Meyer, Stefan, Worthington, Helen V.   +8 more
core   +3 more sources

Management of oral mucositis [PDF]

Archive of Oncology, 2012
Oral mucositis is one of the most common oral complications of cancer treatment. Studies have shown some interventions that reduce the severity of this condition, but there is not a specific treatment proved that really prevents or treats mucositis ...
da Mota Vasconcelos Brasil Catarina, Sampaio Serpa Marianna, de França Talita Ribeiro Tenório, de Jurema Freire Castro Lisboa   +3 more
doaj   +1 more source

Oral platelet gel supernatant plus supportive medical treatment versus supportive medical treatment in the management of radiation-induced oral mucositis: a matched explorative active control trial by propensity analysis [PDF]

, 2017
OBJECTIVES:: In this active control trial, the rate of radio-induced WHO grade 3/4 oral mucositis and the change in quality of life, assessed by OMWQ-HN, were measured in subjects with head and neck cancer treated by platelet gel supernatant (PGS) and ...
Bonfili P, Dell'Orso L, Di Cesare E., Di Staso M, Franzese P, GRAVINA, GIOVANNI LUCA, La Verghetta ME, Marampon F, Masciocchi C, Moro R, Parente S, Reale M, Ruggieri V, Rughetti A, TOMBOLINI, Vincenzo, Vittorini F   +15 more
core   +1 more source

Mukositis Oral dan Kualitas Hidup Spesifik–Mukositis Oral pada Anak Kanker yang Menjalani Kemoterapi

NERS Jurnal Keperawatan, 2017
One of the side effects generally occur during chemotherapy is oral mucositis. Disorders due to oral mucositis often affects the psychological and decreased quality of life of children.
Dwi Novrianda, Yulastri Arif
doaj   +1 more source

A Systematic Review of Recall Regimen and Maintenance Regimen of Patients with Dental Restorations. Part 2: Implant-Borne Restorations [PDF]

, 2015
Purpose To evaluate the current scientific evidence on patient recall and maintenance of implant-supported restorations, to standardize patient care regimens and improve maintenance of oral health. An additional purpose was to examine areas of deficiency
Bidra, Avinash S., Chandler, Nancy Deal, Curtis, Donald A., Daubert, Diane M., Garcia, Lily T., Gauthier, Marissa F., Kosinski, Timothy F., Nenn, Conrad A., Olsen, John A., Platt, Jeffrey A., Wingrove, Susan S.   +10 more
core   +3 more sources