Results 41 to 50 of about 56,513 (348)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Systemic hematogenous dissemination of mouse oral candidiasis is induced by oral mucositis. [PDF]

, 2018
The causes of fungemia include immunosuppression and neutropenia stemming from diverse factors as well as the placement of central venous catheters. However, the relationship between fungemia and the oral cavity has not been substantiated. In this study,
Tanaka, Akira, Kayoko Fukui, Fukui, Kayoko, Katagiri, Hiroki, Kenjirou Nakamura, Akira Tanaka, Nakamura, Kenjirou, Hiroki Katagiri   +7 more
core   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Avaliação dos benefícios da laserterapia no controle da dor causada pela mucosite oral radioinduzida [PDF]

, 2014
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.RESUMO A mucosite oral é uma importante complicação que ocorre durante o tratamento radioterápico na região de cabeça e pescoço.
Guterres, Yasmim
core  

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

The therapeutic effect of PLAG against oral mucositis in hamster and mouse model

Frontiers in Oncology, 2016
Chemotherapy-induced mucositis can limit the effectiveness of cancer therapy and increase the risk of infections. However, no specific therapy for protection against mucositis is currently available.
Ha-Reum Lee, Ha-Reum Lee, Nina Yoo, Sun Young Yoon, Joo Heon Kim, Ki-Young Sohn, Heung-Jae Kim, Myung-Hwan Kim, Jae Wha Kim, Jae Wha Kim   +9 more
doaj   +1 more source

Perigraftitis treatment and histology: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Currently, the two diagnoses of inflammatory peri‐implant diseases are peri‐implant mucositis and peri‐implantitis. The etiology of peri‐implant mucositis and peri‐implantitis is bacterial colonization of the implant. Thus, removal of the implant should eliminate the infection and allow the inflammation to resolve. However, at least
Jonathan H. Do, Charles M. Cobb, John T. Shen   +2 more
wiley   +1 more source

Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study

South Asian Journal of Cancer, 2014
Background: Oral mucositis is the most frequently occurring painful and dose-limiting side-effect of radiation of the head and neck region. Few studies demonstrated that oral glutamine suspension may significantly reduce the duration and severity of ...
Subrata Chattopadhyay, Aramita Saha, Mohammad Azam, Anindya Mukherjee, Prabir Kumar Sur   +4 more
doaj   +1 more source

Perigraftitis, an independent biologic complication associated with implants placed in grafted bone

Clinical Advances in Periodontics, EarlyView.
Abstract Background Perigraftitis is a recently introduced concept describing biologic complications specifically associated with implants placed in grafted bone. It is characterized by inflammation resulting from bacterial colonization of grafted bone and/or residual graft particulates.
Jonathan H. Do, Charles M. Cobb, John T. Shen   +2 more
wiley   +1 more source