Results 51 to 60 of about 53,349 (300)

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

Estudo comparativo de diferentes protocolos de laserterapia na ação analgésica e no reparo da mucosite oral radioinduzida associada ou não à quimioterapia [PDF]

, 2015
Disertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2015.O câncer configura-se como um problema de saúde pública mundial e tem como principais tratamentos a
Minamisako, Maria Comparotto
core  

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Mucosite peri-implantar: qual o melhor tratamento? [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.Objetivo: Avaliar a melhor terapia para o tratamento da mucosite periimplantar. Metodologia: Foram avaliados 64 implantes com mucosite periimplantar.
Ouriques, Felipe Damerau
core  

Outcomes sensitive to nursing service quality in ambulatory cancer chemotherapy: systematic scoping review

, 2012
Background: there is long standing interest in identifying patient outcomes that are sensitive to nursing care and an increasing number of systems that include outcomes in order to demonstrate or monitor the quality of nursing care.Objective: we ...
Alison Richardson, Peter Griffiths, Blackwell, Rebecca, Rebecca Blackwell, Richardson, Alison, Griffiths, Peter   +5 more
core   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Longitudinal Swallowing and Salivary Changes With CLR 131 and Re‐Irradiation in Recurrent Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Patients with recurrent head and neck cancer (HNC) often present with severe, persistent dysphagia and xerostomia following prior chemoradiation. Although swallowing impairments and salivary dysfunction have been reported in this population, prior longitudinal studies have not examined changes in salivary composition or how these ...
Jenni Wu, Sara Gustafson, Meredith Hyun, Roxana Alexandridis, Mark Nicosia, Timothy McCulloch, Justine Bruce, Randall Kimple, Nicole Rogus‐Pulia   +8 more
wiley   +1 more source

Vitamin C and L-arginine as potential synergistic adjuvants to recover intestinal mucositis induced by chemotherapy

Clinical Nutrition Open Science
s u m m a r y: Purpose: Chemotherapy-induced intestinal mucositis is a debilitating condition often triggered by 5-fluorouracil (5-FU). This study investigated the effect of vitamin C alone and combined with L-arginine, in a murine model of 5-FU-induced
Amanda Dias Borges, Raquel Baumgratz Marques, Luiz Octávio Pires, Luísa Martins Trindade, Nayara Salgado Vieira Sette, Maria Emília Rabelo Andrade, Samanta Thomas-Valdés, Paola Caroline Lacerda Leocádio, Jacqueline Isaura Alvarez-Leite, Fernanda Rezende Souza, Geovanni Dantas Cassali, Ramon de Oliveira Souza, Flaviano dos Santos Martins, Valbert Nascimento Cardoso, Simone de Vasconcelos Generoso, Simone Odília Antunes Fernandes   +15 more
doaj   +1 more source

“It's the Exact Same Treatment … Except Only 5 Min Away”: A RE‐AIM Evaluation of a Speech‐Language Pathology Shared‐Care Model for Rural Patients With Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Challenges accessing post‐treatment speech‐language pathology (SLP) services can add to treatment burden for rural patients with head and neck cancer (HNC). Hence, the aim of this study was to evaluate a shared‐care SLP service designed to support local SLP access for patients with HNC, using the RE‐AIM framework.
Corey Patterson, Elizabeth C. Ward, Rebecca L. Packer, Jasmine Foley, Laurelie R. Wishart, Clare L. Burns, Sally Pether, Wendy Comben   +7 more
wiley   +1 more source

Methotrexate and mucositis: A merry-go-round for oncologists

Indian Journal of Medical and Paediatric Oncology, 2019
High-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies. Mucositis is a well-known, dose-related side effect of methotrexate.
Kundan Mishra, Aditya Jandial, Anil Kumar, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Pankaj Malhotra   +6 more
doaj   +1 more source