Results 71 to 80 of about 56,513 (348)

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis

Integrative Cancer Therapies, 2018
Background: Chemoradiotherapy-associated mucositis can manifest as pain, inflammation, dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose-limiting side effect of chemotherapy, affecting nutritional intake and oral
Michael Thomsen MSc, Luis Vitetta PhD
doaj   +1 more source

A importância do cirurgião dentista antes e após o transplante de medula óssea: uma revisão de literatura [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O transplante de medula óssea (TMO) é, atualmente, o tratamento de eleição para diversas doenças que afetam a produção de células mãe hematopoiéticas e de ...
Lessa, Luiza Silveira
core  

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, EarlyView.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

An increase in Fusobacterium is associated with the severity of oral mucositis after radiotherapy

Scientific Reports
Radiotherapy is a common treatment for head and neck cancer but often causes oral mucositis, which reduces quality of life. Recent studies suggest that radiotherapy affects the oral microbiota, but whether it contributes to the severity of mucositis has ...
Atsushi Ue, Yukihisa Tamaki, Haruki Usuda, Unta Yamamori, Hiroshi Burioka, Natsuko Nagano, Masafumi Uno, Yoko Sonoyama, Takayuki Okamoto, Koichiro Wada   +9 more
doaj   +1 more source

Patient experiences with oral mucositis caused by chemo-/radiotherapy: a critical qualitative literature review

Nursing Reports, 2014
Mucositis is one of the most common side effects of chemotherapy and radiotherapy. In order to develop an evidence-based clinical practice guideline for the management of tumor therapy-induced-oral mucositis, it was necessary to capture the patients ...
Daniela Zanolin, Christine Widmer, Eva-Maria Panfil   +2 more
doaj   +1 more source

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

Tratamento odontológico para pacientes submetidos à radioterapia em região de cabeça e pescoço: uma revisão de literatura [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.As neoplasias de cabeça e pescoço apresentam grande incidência no país. O prognóstico tardio dos carcinomas ainda é uma realidade, implicando terapias mais
Torres, Bruno Lucas Buzzi
core  

Th17-related cytokines in mucositis: Is there any difference between peri-implantitis and periodontitis patients?

, 2017
Objective: This study aimed to compare Th17-related cytokines named IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in peri-implant fluid (PIF) from mucositis sites in patients having either ...
Telles, Daniel Moraes, Silva Teixeira, Mayla Kezy, Figueredo, Carlos Marcelo, Veras Lourenço, Eduardo José, Lira-Junior, Ronaldo   +4 more
core   +1 more source

The Effect of Rabdosia rubescens on Radiotherapy-Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients: A Phase II Clinical Study

Integrative Cancer Therapies
Purpose: Radiotherapy-induced oral mucositis is the most common side effect in nasopharyngeal carcinoma (NPC) patients. We aimed to evaluate the efficacy and safety of Rabdosia rubescens drop pills in NPC patients with radiation-induced oral mucositis ...
Lu Li MS, Yecai Huang MD, Jun Yin MD, Peng Xu MS, Mei Lan MD, Churong Li MS, Yunxiang Qi MD, Ke Xu MS, Bosen Li MS, Yukun Luo MS, Qinghua Jiang MS, Shanshan Peng MS, Jinyi Lang MD, Mei Feng MD   +13 more
doaj   +1 more source