Results 71 to 80 of about 48,706 (299)

Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice [PDF]

This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy.
Azuma, Kazuo, 50194410, Okamoto, Yoshiharu, 2273, Imagawa, Tomohiro, 80264654, Osaki, Tomohiro, 100001158, 2885, 100000741, 30432610, 20232605, Ito, Norihiko, 70402980, 100000469, 100000602, Ochi, Kosuke, 4721, 100000923, 4868, 100000607, 50721841, 4641, Tsuka, Takeshi, Izawa, Hironori, Morimoto, Minoru, 26766, 26765, Saimoto, Hiroyuki, 4816, Koizumi, Ryo, 100001168, Ifuku, Shinsuke, 100000597, 40431332, 10273880, 50643235, 20186977, 4897, 100000515, 100000637, 4711, 4634, 4637   +43 more
core   +1 more source

Immunotherapeutic Approaches to Head and Neck Squamous Cell Carcinoma: Current Clinical Practice and Future Directions

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) is frequently diagnosed at advanced stages and has historically been associated with poor outcomes. Immune checkpoint inhibition has transformed the therapeutic landscape, offering durable responses in recurrent, metastatic, and locally advanced disease.
Carol R. Bradford, Sreeram M. P., Karthik N. Rao, Orlando Guntinas‐Lichius, Nabil Saba, Alfio Ferlito   +5 more
wiley   +1 more source

Oral mucosa tissue gene expression profiling before, during, and after radiation therapy for tonsil squamous cell carcinoma.

PLoS ONE, 2018
BACKGROUND:Radiation-therapy (RT) induces mucositis, a clinically challenging condition with limited prophylactic interventions and no predictive tests.
Mette Marcussen, Mads Sønderkær, Julie Støve Bødker, Maria Andersen, Søren Nielsen, Charles Vesteghem, Ilse Christiansen, Olav Jonas Bergmann, Martin Bøgsted, Karen Dybkær, Mogens Vyberg, Hans Erik Johnsen   +11 more
doaj   +1 more source

A importância do cirurgião dentista antes e após o transplante de medula óssea: uma revisão de literatura [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O transplante de medula óssea (TMO) é, atualmente, o tratamento de eleição para diversas doenças que afetam a produção de células mãe hematopoiéticas e de ...
Lessa, Luiza Silveira
core  

Strategies in Management of Oral Mucositis [PDF]

, 2010
Oral mucositis is a clinically important and sometimes dose-limiting complication of Cancer Therapy. Mucositis lesions are painful, affect nutrition, quality of life and often hampers continuity of the treatment modality.
Sonal Vahanwala, Sandeep Pagare
core   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

The Effect of Rabdosia rubescens on Radiotherapy-Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients: A Phase II Clinical Study

Integrative Cancer Therapies
Purpose: Radiotherapy-induced oral mucositis is the most common side effect in nasopharyngeal carcinoma (NPC) patients. We aimed to evaluate the efficacy and safety of Rabdosia rubescens drop pills in NPC patients with radiation-induced oral mucositis ...
Lu Li MS, Yecai Huang MD, Jun Yin MD, Peng Xu MS, Mei Lan MD, Churong Li MS, Yunxiang Qi MD, Ke Xu MS, Bosen Li MS, Yukun Luo MS, Qinghua Jiang MS, Shanshan Peng MS, Jinyi Lang MD, Mei Feng MD   +13 more
doaj   +1 more source

Patient experiences with oral mucositis caused by chemo-/radiotherapy: a critical qualitative literature review

Nursing Reports, 2014
Mucositis is one of the most common side effects of chemotherapy and radiotherapy. In order to develop an evidence-based clinical practice guideline for the management of tumor therapy-induced-oral mucositis, it was necessary to capture the patients ...
Daniela Zanolin, Christine Widmer, Eva-Maria Panfil   +2 more
doaj   +1 more source

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, EarlyView.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

An increase in Fusobacterium is associated with the severity of oral mucositis after radiotherapy

Scientific Reports
Radiotherapy is a common treatment for head and neck cancer but often causes oral mucositis, which reduces quality of life. Recent studies suggest that radiotherapy affects the oral microbiota, but whether it contributes to the severity of mucositis has ...
Atsushi Ue, Yukihisa Tamaki, Haruki Usuda, Unta Yamamori, Hiroshi Burioka, Natsuko Nagano, Masafumi Uno, Yoko Sonoyama, Takayuki Okamoto, Koichiro Wada   +9 more
doaj   +1 more source