Results 21 to 30 of about 73,485 (336)

A Phase I Study of Abiraterone Acetate Combined with BEZ235, a Dual PI3K/mTOR Inhibitor, in Metastatic Castration Resistant Prostate Cancer. [PDF]

, 2017
Lessons learnedThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate ...
Friedlander, Terence, Hsieh, Andrew C, Kim, Won, Lin, Amy M, Louttit, Mirela, Ryan, Charles J, Wei, Xiao X   +6 more
core   +1 more source

Research progress on animal models of oral mucositis caused by radiotherapy and chemotherapy

口腔疾病防治, 2020
Inflammation of the oral mucosa induced by radiotherapy and/or chemotherapy may cause pain, difficulty speaking and swallowing, an increased risk of local and systemic infections, and even interrupt cancer treatment, which can seriously affect a patient ...
ZOU Xiaolong, CHEN Yuan, WANG Yan, WANG Jiantao   +3 more
doaj   +1 more source

Management of oral mucositis [PDF]

Archive of Oncology, 2012
Oral mucositis is one of the most common oral complications of cancer treatment. Studies have shown some interventions that reduce the severity of this condition, but there is not a specific treatment proved that really prevents or treats mucositis ...
da Mota Vasconcelos Brasil Catarina, Sampaio Serpa Marianna, de França Talita Ribeiro Tenório, de Jurema Freire Castro Lisboa   +3 more
doaj   +1 more source

Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. [PDF]

, 2016
Preclinical models suggest that histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) inhibitors have synergistic anticancer activity. We designed a phase I study to determine the safety, maximum tolerated dose (MTD), recommended phase II ...
Falchook, Gerald S., Fanale, Michelle A., Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S., Janku, Filip, Kaseb, Ahmed O., Kurzrock, Razelle, Meric-Bernstam, Funda, Naing, Aung, Park, Haeseong, Patel, Shreyaskumar, Piha-Paul, Sarina A., Subbiah, Vivek, Tsimberidou, Apostolia M., Velez-Bravo, Vivianne M M., Wheler, Jennifer J., Zinner, Ralph G.   +17 more
core   +5 more sources

Mucosal dendritic cells shape mucosal immunity [PDF]

Experimental & Molecular Medicine, 2014
Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells.
Mi-Na Kweon, Sun-Young Chang, Hyun-Jeong Ko   +2 more
openaire   +3 more sources

Phase 1b/2a trial of the superoxide dismutase mimetic GC4419 to reduce chemoradiotherapy-induced oral mucositis in patients with oral cavity or oropharyngeal carcinoma [PDF]

, 2018
PURPOSE: To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin for patients with oral cavity or oropharyngeal cancer (OCC) and to assess the potential of GC4419 to reduce severe oral ...
Adkins, Douglas, Agarwala, Sanjiv S, Allen, Bryan G, Anderson, Carryn M, Brill, Jeffrey M, Buatti, John M, Chen, Yuhchyau, Holmlund, Jon T, Lee, Christopher M, Mould, Diane R, Sonis, Stephen T, Sun, Wenqing, Venigalla, Madhavi L, Zhen, Weining   +13 more
core   +2 more sources

Oral mucositis

National Journal of Maxillofacial Surgery, 2020
Oral mucositis is one of the most common complications of cancer therapy. It is a nonhematologic complication of cytotoxic chemotherapy and radiotherapy and reduces the quality of life. It is estimated that 40% the cases on standard chemotherapy may develop oral mucositis.
Singh, Vibha, Singh, Akhilesh Kumar
openaire   +3 more sources

Mukositis Oral dan Kualitas Hidup Spesifik–Mukositis Oral pada Anak Kanker yang Menjalani Kemoterapi

NERS Jurnal Keperawatan, 2017
One of the side effects generally occur during chemotherapy is oral mucositis. Disorders due to oral mucositis often affects the psychological and decreased quality of life of children.
Dwi Novrianda, Yulastri Arif
doaj   +1 more source

Systematic Review of Laser and Other Light Therapy for the Management of Oral Mucositis in Cancer Patients [PDF]

, 2012
Background The aim of this study was to review the available literature and define clinical practice guidelines for the use of laser and other light therapies for the prevention and treatment of oral mucositis.
Brian Hodgson, Cesar Migliorati, Cherry L. Estilo, Heliton Spindola Antunes, Ian Hewson, Joanne Bowen, Mark M. Schubert, Nilza Nelly Fontana Lopes, null null, Rajesh V. Lalla, Sharon Elad   +10 more
core   +2 more sources

Oral platelet gel supernatant plus supportive medical treatment versus supportive medical treatment in the management of radiation-induced oral mucositis: a matched explorative active control trial by propensity analysis [PDF]

, 2017
OBJECTIVES:: In this active control trial, the rate of radio-induced WHO grade 3/4 oral mucositis and the change in quality of life, assessed by OMWQ-HN, were measured in subjects with head and neck cancer treated by platelet gel supernatant (PGS) and ...
Bonfili P, Dell'Orso L, Di Cesare E., Di Staso M, Franzese P, GRAVINA, GIOVANNI LUCA, La Verghetta ME, Marampon F, Masciocchi C, Moro R, Parente S, Reale M, Ruggieri V, Rughetti A, TOMBOLINI, Vincenzo, Vittorini F   +15 more
core   +1 more source