Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus. [PDF]
, 2014 BackgroundBevacizumab and temsirolimus are active agents in gynecologic tumors. Temsirolimus attenuates upregulation of HIF-1α levels, a resistance mechanism for antiangiogenics, and targets the PI3-kinase/AKT/mTOR axis, commonly aberrant in these tumors.
Falchook, Gerald S +9 more
core +7 more sources
Examination of nursing theses on oral mucositis in children with cancer in Turkey
Problemy PielęgniarstwaOral mucositis is common in children with cancer. Nurses are effective in the management of oral mucositis. For this reason, the study was conducted to examine nursing theses regarding oral mucositis in children with cancer in Turkey.
Şule Çalışır Kundakçı +2 more
doaj +1 more source
First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma. [PDF]
, 2020 PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to ...
Cloughesy, Timothy F +11 more
core
NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients [PDF]
, 2002 Objective: The purpose of this study was to determine the effects of prophylactic near-infrared light therapy from light-emitting diodes (LEDs) in pediatric bone marrow transplant (BMT) recipients.
Barbeau, Lori +10 more
core +1 more source
NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea [PDF]
, 2001 This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program. LED-technology developed for NASA plant growth experiments in space shows promise for delivering light deep into tissues of the body to promote wound healing ...
Buchmann, Ellen V. +14 more
core +1 more source
A pilot study of temsirolimus and body composition. [PDF]
, 2013 PurposeBody weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss ...
Janku, Filip +6 more
core +2 more sources
The therapeutic effect of PLAG against oral mucositis in hamster and mouse model
Frontiers in Oncology, 2016 Chemotherapy-induced mucositis can limit the effectiveness of cancer therapy and increase the risk of infections. However, no specific therapy for protection against mucositis is currently available.
Ha-Reum Lee +9 more
doaj +1 more source
South Asian Journal of Cancer, 2014 Background: Oral mucositis is the most frequently occurring painful and dose-limiting side-effect of radiation of the head and neck region. Few studies demonstrated that oral glutamine suspension may significantly reduce the duration and severity of ...
Subrata Chattopadhyay +4 more
doaj +1 more source
Nutritional and Post-Transplantation Outcomes of Enteral versus Parenteral Nutrition in Pediatric Hematopoietic Stem Cell Transplantation: A Systematic Review of Randomized and Nonrandomized Studies [PDF]
, 2019 Hematopoietic stem cell transplantation (HSCT) involves the administration of chemotherapy followed by the infusion of donor stem cells. After treatment, children can consequently experience nausea, vomiting, diarrhea, anorexia, and mucositis, which ...
Evans, J. C. +2 more
core +1 more source
Journal of Radiation and Cancer Research, 2021 Context: Study to reduce oral mucositis using chronoradiotherapy. Aims: This study aims to assess and compare oral mucositis and weight loss between two groups of patients on radiation-morning and evening group.
Lithika M Lavanya, T R Arulponni
doaj +1 more source