Results 11 to 20 of about 2,128 (197)

Citrus Flavonoids for Cystic Fibrosis Treatment. [PDF]

Chembiochem
Studies conducted since the late 1990s show substantial activity of selected citrus flavonoids as cystic fibrosis transmembrane conductance regulator (CFTR) membrane protein activators. The thesis of this work is that aptly formulated citrus flavonoids hold sigificant potential for developing a multitarget treatment of cystic fibrosis combining in a ...
Pagliaro M, Di Sano C, D'Anna C, Li Petri G, Angellotti G, Ciriminna R.   +5 more
europepmc   +2 more sources

Endoscopically assessed mucus parameters in equine asthma: Relationship to clinical history and cytological findings data. [PDF]

Equine Vet J
Abstract Background Mucus parameters are hallmark diagnostic features of equine asthma (EA). Objectives To investigate the relationship between mucus quantity score and mucus viscosity score with signalment, history, clinical findings and cytological parameters. Study Design Retrospective cross‐sectional study.
Drespling J, Berwanger L, Kühn H, Schwarz B, Doherr M, Mundhenk L.   +5 more
europepmc   +2 more sources

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium. [PDF]

Acta Physiol (Oxf)
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Amiri M, Salari A, Seidler U.
europepmc   +2 more sources

Ethics Committees' Practices in Healthcare, Banking and Research: Key Requirements for Their Functionality. [PDF]

J Eval Clin Pract
ABSTRACT Rationale To meet concerns about ethical and unethical behavior in their work environments and workplaces, organizations began establishing ethics programs that contain ethics committees (ECs). There is now a tradition and diverse use of ECs for ethical decision‐making in many different organizational settings.
Arık T, Michl S.
europepmc   +2 more sources

Effects of modulator therapies on endocrine complications in adults with cystic fibrosis: a narrative review

Medical Journal of Australia, Volume 219, Issue 10, Page 496-502, November 2023., 2023
Summary Cystic fibrosis is a monogenic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which transports chloride ions in secretory organs. Modulator therapies are small molecules that correct CFTR dysfunction and can lead to a wide range of benefits for both pulmonary and extrapulmonary ...
Shanal Kumar, Georgia Soldatos, Helena J Teede, Michael Pallin   +3 more
wiley   +1 more source

Measurement of Trogocytosis: Quantitative Analyses Validated with Rigorous Controls

Current Protocols, Volume 3, Issue 10, October 2023., 2023
Abstract Trogocytosis is a process in which receptors on acceptor cells remove and internalize cognate ligands from donor cells. Trogocytosis has a profound and negative impact on mAb‐based cancer immunotherapy, as seen in the treatment of chronic lymphocytic leukemia (CLL) with CD20 mAbs, such as rituximab (RTX) and ofatumumab (OFA).
Ronald P. Taylor, Margaret A. Lindorfer
wiley   +1 more source

Spatial Single Cell Analysis of Proteins in 2D Human Gastruloids Using Iterative Immunofluorescence

Current Protocols, Volume 3, Issue 10, October 2023., 2023
Abstract During development, cell signaling instructs tissue patterning, the process by which initially identical cells give rise to spatially organized structures consisting of different cell types. How multiple signals combinatorially instruct fate in space and time remains poorly understood.
Emily Freeburne, Seth Teague, Hina Khan, Bolin Li, Siyuan Ding, Bohan Chen, Adam Helms, Idse Heemskerk   +7 more
wiley   +1 more source

International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A. Roberts, Thomas Tängdén, Athena Zuppa, Marc H. Scheetz   +16 more
wiley   +1 more source

Isolation of Adult Mouse Cardiac Fibroblasts

Current Protocols, Volume 3, Issue 7, July 2023., 2023
Abstract Fibroblasts are dynamic cells of mesenchymal origin that regulate tissue homeostasis, extracellular matrix production, and acute wound healing. Fibroblasts respond to tissue injury and inflammation by differentiating into myofibroblasts and secreting extracellular matrix proteins.
Abir Almazloum, Hadi Khalil
wiley   +1 more source

DIAGNOSTIC PROBLEMS OF MUCOVISCIDOSIS AND WAYS OF SOLUTION IN RUSSIA

Педиатрическая фармакология, 2014
Mucoviscidosis is a monogenic autosomal recessive caused by the CFTR gene mutations and characterized by pronounced genetic heterogeneity and clinical polymorphism, which emphasizes the need in comprehensive diagnosis and molecular-genetic verification ...
A. A. Baranov, N. I. Kapranov, N. Yu. Kashirskaya, L. S. Namazova-Baranova, V. D. Sherman, O. I. Simonova, A. Yu. Tomilova, K. V. Sevost'yanov, A. M. Pushkov, A. L. Vladykin, N. V. Shatokhin   +10 more
doaj   +1 more source