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The role of goblet cells and mucus in intestinal homeostasis

Nature Reviews Gastroenterology and Hepatology, 2022
Malin E V Johansson
exaly   +2 more sources

Mucus Penetration of Surface-Engineered Nanoparticles in Various pH Microenvironments.

ACS Nano, 2023
The penetration behavior of nanoparticles in mucous depends on physicochemical properties of the nanoparticles and the mucus microenvironment, due to particle-mucin interactions and the presence of the mucin mesh space filtration effect.
Yiyang Guo   +8 more
semanticscholar   +1 more source

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation

Science immunology, 2022
Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the colonic host-microbe interactions that help maintain gut homeostasis.
Jian Zhang   +17 more
semanticscholar   +1 more source

Mucus Plugs Persist in Asthma and Changes in Mucus Plugs Associate with Changes in Airflow Over Time.

American Journal of Respiratory and Critical Care Medicine, 2022
RATIONALE Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug phenotype.
Monica Tang   +24 more
semanticscholar   +1 more source

Untangling Mucosal Drug Delivery: Engineering, Designing, and Testing Nanoparticles to Overcome the Mucus Barrier.

ACS Biomaterials Science & Engineering, 2022
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in the human body. High vascularization and accessibility have motivated drug delivery to various mucosal surfaces; however, these benefits are hindered by the ...
Jeffrey Watchorn   +5 more
semanticscholar   +1 more source

Mucus Pharmacology

Respiration, 1991
Until recently the experimental and clinical possibilities for investigation of the pharmacological effects of drugs acting on airway secretions were limited. Nowadays, new biological, physical and chemical techniques of investigation are applied to 'mucology', providing better characterization of this class of drugs.
openaire   +2 more sources

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