Results 81 to 90 of about 386,514 (347)

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Gut Microbes
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined.
Yan Chen, Ashley Gilliland, Qiaochu Liang, Xiao Han, Hyungjun Yang, Jocelyn Chan, Dominique Lévesque, Kyung-Mee Moon, Parandis Daneshgar, François-Michel Boisvert, Leonard Foster, Wesley F. Zandberg, Kirk Bergstrom, Hong B. Yu, Bruce A. Vallance   +14 more
doaj   +1 more source

Marine snow formation in the aftermath of the Deepwater Horizon oil spill in the Gulf of Mexico

Environmental Research Letters, 2012
The large marine snow formation event observed in oil-contaminated surface waters of the Gulf of Mexico (GoM) after the Deepwater Horizon accident possibly played a key role in the fate of the surface oil.
U Passow, K Ziervogel, V Asper, A Diercks   +3 more
doaj   +1 more source

Mathematical Modeling of Mucociliary Clearance: A Mini-Review

Cells, 2019
Mucociliary clearance is an important innate host defense of the mammalian respiratory system, as it traps foreign substances, including pollutants, pathogens, and allergens, and transports them out of the airway.
Ling Xu, Yi Jiang
doaj   +1 more source

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Frontiers in Cellular and Infection Microbiology, 2020
Mucus is integral to gut health and its properties may be affected in neurological disease. Mucus comprises a hydrated network of polymers including glycosylated mucin proteins.
M. Herath, S. Hosie, J. Bornstein, Ashley E. Franks, E. Hill-Yardin   +4 more
semanticscholar   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Sulphide donors affect the expression of mucin and sulphide detoxification genes in the mucosal organs of Atlantic salmon (Salmo salar)

Frontiers in Physiology, 2022
Hydrogen sulphide (H2S) is a gas that affects mucosal functions in mammals. However, its detrimental effects are less understood in fish despite being known to cause mass mortality. Here we used explant models to demonstrate the transcriptional responses
Hanna Ross D. Alipio, Hanna Ross D. Alipio, Nora Albaladejo-Riad, Carlo C. Lazado   +3 more
doaj   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Phosphatidylcholine in Intestinal Mucus Protects against Mucosal Invasion of Microbiota and Consequent Inflammation

Livers
Intestinal mucus serves as the first line barrier within the mucosa to protect against microbiota attack due to its water-repellent properties, which are the result of the high abundance of phosphatidylcholine bound to mucins.
Wolfgang Stremmel, Ralf Weiskirchen
doaj   +1 more source

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF [PDF]

, 2013
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases.
Albanese CT, An Staes, Carlos López‐Otin, Claude Libert, Elien Van Wonterghem, Eline Dejonckheere, Filip Van Hauwermeiren, Kitagawa H, Kris Gevaert, Lesuffleur T, Nusrat A, Riet De Rycke, Roosmarijn E. Vandenbroucke, Schmitz H, Smirnova MG, Sofie Lodens   +15 more
core   +3 more sources