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Airway goblet-cell mucus secretion

Trends in Pharmacological Sciences, 2001
A mucus hypersecretory phenotype is a dominant characteristic of chronic airways diseases such as chronic bronchitis and asthma. This phenotype develops following chronic exposure of the respiratory tract to particulate matter, allergens, irritants and/or pathogens.
exaly   +3 more sources

Rosmarinic Acid Restores Colonic Mucus Secretion in Colitis Mice by Regulating Gut Microbiota-Derived Metabolites and the Activation of Inflammasomes.

Journal of Agricultural and Food Chemistry, 2023
Maintaining a steady state of mucus barrier is an important potential target for polyphenol to exert its anticolitis activity. This study elucidates the pivotal role of polyphenol rosmaric acid (RA) in regulating the mucus barrier function and ...
Qun Wang   +5 more
semanticscholar   +1 more source

Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR/ROS/ERK pathway.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Excessive secretion of airway mucus may be an important pathological factor of air pollution-induced acute asthma attacks. Treatment of airway mucus hypersecretion improves asthma aggravated by air pollutants. Qufeng Xuanbi
Bo-Han Wang   +11 more
semanticscholar   +1 more source

Airway Mucus Secretion

Physiology, 1990
Mucus secretion into the airways is mainly under vagal cholinergic control, and its volume and composition are modulated by sympathetic (adrenergic) and peptidergic mechanisms. Inflammatory mediators also change the secretion. The various compositions of mucus have been little explored, and the importance of its changes in disease is little understood.
JG Widdicombe, SE Webber
openaire   +1 more source

TMEM16A is indispensable for basal mucus secretion in airways and intestine

The FASEB Journal, 2019
Transmembrane member 16A (TMEM16A) is the Ca2+‐activated chloride channel in airways and intestine. It has been associated with goblet cell metaplasia, as expression of TMEM16A is strongly up‐regulated in cystic fibrosis and asthma during mucus ...
R. Benedetto   +3 more
semanticscholar   +1 more source

Dopamine promotes colonic mucus secretion through dopamine D5 receptor in rats.

American Journal of Physiology - Cell Physiology, 2019
Dopamine regulates gastrointestinal mucosal barrier. Mucus plays important roles in the protection of intestinal mucosa. Here, the regulatory effect of dopamine on rat colonic mucus secretion was investigated.
Yun Li   +8 more
semanticscholar   +1 more source

Effect of NF-κB signal pathway on mucus secretion induced by atmospheric PM2.5 in asthmatic rats.

Ecotoxicology and Environmental Safety, 2019
BACKGROUND Exposure to PM2.5 can stimulate the mucus secretion of airway, affecting the development of bronchial asthma. NF-κB signal pathway plays an important role in inflammation and dysimmunity, what may contribute to the mucus secretion. The present
Ying Liu   +5 more
semanticscholar   +1 more source

The viscoelastic nature of mucus secretion

Chest, 1981
The viscoelastic properties of mucus have been described together with the methods which can be used to evaluate such a rheologically complex system. Methods which do not take into account the viscoelastic nature of mucus have been criticized and it is concluded that only creep or oscillatory tests yield significant correlations with mucociliary ...
openaire   +2 more sources

Mucus-secreting presacral cyst

The Japanese Journal of Surgery, 1986
A mucus-secreting presacral cyst was found in a 49-year-old woman who complained of dysuria. A routine rectal digital examination revealed a retrorectal mass. Diagnostic imaging demonstrated a large presacral cystic tumor. The cyst was removed through a transsacral approach.
Y, Tajima   +5 more
openaire   +2 more sources

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