Abnormal Airway Mucus Secretion Induced by Virus Infection [PDF]
Frontiers in Immunology, 2021 The airway mucus barrier is a primary defensive layer at the airway surface. Mucins are the major structural components of airway mucus that protect the respiratory tract.
Xiao Xiao Tang, Tang Xiao Xiao
exaly +5 more sources
Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine [PDF]
Scientific ReportsThe Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion.
Jiraporn Ousingsawat +10 more
doaj +3 more sources
Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo [PDF]
Journal of Ginseng Research, 2022 Background: Cigarette smoke (CS) is considered a principal cause of chronic obstructive pulmonary disease (COPD) and is associated with mucus hypersecretion and airway inflammation.
Jae-Won Lee +13 more
doaj +3 more sources
Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress
Cell Host and Microbe, 2023 Summary Colonic goblet cells are specialized epithelial cells that secrete mucus to physically separate the host and its microbiota, thus preventing bacterial invasion and inflammation. How goblet cells control the amount of mucus they secrete is unclear.
Shai Bel, Meital Nuriel-Ohayon
exaly +3 more sources
CD147 increases mucus secretion induced by cigarette smoke in COPD [PDF]
BMC Pulmonary Medicine, 2019 Background CD147 is expressed in many tissues and is involved in many inflammatory diseases. Emerging evidence suggests that the overproduction of mucus is a malignant factor in chronic obstructive pulmonary disease (COPD), which results in severe airway
Qiao Yu +3 more
doaj +3 more sources
Autophagy-ER stress crosstalk controls mucus secretion and susceptibility to gut inflammation [PDF]
Autophagy, 2023 Mucus secretion from colonic goblet cells is an important host defense mechanism against the harsh lumenal environment. Yet how mucus secretion is regulated is not well understood.
Maria Naama, Shai Bel
semanticscholar +2 more sources
Intestinal mucus components and secretion mechanisms: what we do and do not know
Experimental and Molecular Medicine, 2023 Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as inflammatory bowel disease and colorectal cancer, and disorder in extraintestinal organs.
Chunyan Song +5 more
doaj +2 more sources
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion [PDF]
J Exp Med, 2021 The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully illustrated. Here, we identify that Forkhead box protein O1 (Foxo1) is critical for gut commensalism and intestinal barrier integrity ...
Zuojia Chen +16 more
semanticscholar +2 more sources
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport [PDF]
Sci Signal, 2022 Goblet cells in the small intestinal crypts contain large numbers of mucin granules that are rapidly discharged to clean bacteria from the crypt. Because acetylcholine released by neuronal and nonneuronal cells controls many aspects of intestinal ...
B. Dolan +4 more
semanticscholar +2 more sources
Antibacterial, Antibiofilm and Anti-Virulence Activity of Biactive Fractions from Mucus Secretion of Giant African Snail Achatina fulica against Staphylococcus aureus Strains [PDF]
Antibiotics (Basel), 2021 Staphylococcus aureus is an important etiological agent that causes skin infections, and has the propensity to form biofilms, leading to significant mortality and morbidity in patients with wounds.
Libardo Suárez +3 more
semanticscholar +2 more sources