Results 121 to 130 of about 775 (136)
A folded conformation of MukBEF and cohesin [PDF]
Nature Structural and Molecular Biology, 2019 Structural maintenance of chromosomes (SMC)-kleisin complexes organize chromosomal DNAs in all domains of life, with key roles in chromosome segregation, DNA repair and regulation of gene expression.
Frank Bürmann +2 more
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Mechanics of DNA bridging by bacterial condensin MukBEF in vitro and in singulo [PDF]
EMBO Journal, 2010 Structural maintenance of chromosome (SMC) proteins comprise the core of several specialized complexes that stabilize the global architecture of the chromosomes by dynamically linking distant DNA fragments. This reaction however remains poorly understood giving rise to numerous proposed mechanisms of the proteins.
Weifeng She, Valentin V Rybenkov
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Chromosome Condensation in the Absence of the Non-SMC Subunits of MukBEF [PDF]
Journal of Bacteriology, 2006 ABSTRACTMukBEF is a bacterial SMC (structural maintenance of chromosome) complex required for chromosome partitioning inEscherichia coli. We report that overproduction of MukBEF results in marked chromosome condensation. This condensation is rapid and precedes the effects of overproduction on macromolecular synthesis.
Valentin V Rybenkov
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MukBEF on the march: taking over chromosome organization in bacteria? [PDF]
Molecular Microbiology, 2011 SummarySmc–ScpAB complexes, also called bacterial condensin, are comprised of highly conserved proteins present in a wide variety of bacteria and archaea. They facilitate bacterial chromosome segregation probably by organizing and/or compacting nascent sister chromosomes.
Stephan Gruber
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The Escherichia coli SMC Complex, MukBEF, Shapes Nucleoid Organization Independently of DNA Replication [PDF]
Journal of Bacteriology, 2012 ABSTRACTSMC (structuralmaintenance ofchromosomes) complexes function ubiquitously in organizing and maintaining chromosomes. Functional fluorescent derivatives of theEscherichia coliSMC complex, MukBEF, form foci that associate with the replication origin region (ori).
Anjana Badrinarayanan +2 more
exaly +4 more sources
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The Bacterial Condensin MukBEF Compacts DNA into a Repetitive, Stable Structure
Science, 2004Condensins are conserved proteins containing SMC (structural maintenance of chromosomes) moieties that organize and compact chromosomes in an unknown mechanism essential for faithful chromosome partitioning. We show that MukBEF, the condensin in Escherichia coli , cooperatively compacts a single DNA molecule into a ...
Ryan B, Case +5 more
openaire +2 more sources
Novobiocin Susceptibility of MukBEF-Deficient Escherichia coli Is Combinatorial with Efflux and Resides in DNA Topoisomerases [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACT Condensins play a key role in the global organization of bacterial chromosomes. In Escherichia coli , the inactivation of its sole condensin MukBEF induces severe growth defects and renders cells hypersusceptible to novobiocin.
Helen I Zgurskaya, Valentin V Rybenkov
exaly +3 more sources