The hormonal composition of follicular fluid and its implications for ovarian cancer pathogenesis [PDF]
Ovulation has long been associated with an increased risk in ovarian cancer, yet the underlying molecular mechanisms remain obscure. Two aspects of ovulation have been linked to ovarian cancer pathogenesis.
Drapkin, Ronny, Emori, Megan M
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Novi uvidi u predskazivanju ovarijskog hiperstimulacijskog sindroma [PDF]
Ovarian hyperstimulation syndrome is the most dangerous complication following the administration of gonadotropins. There is no preventive and pharmacological intervention that can fully prevent development of this syndrome.
Miro Kasum, Slavko Orešković
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Clinical Implication of Targeting of Cancer Stem Cells [PDF]
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M +82 more
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ABSTRACT Aim This study aimed to investigate institutional factors associated with the clinical implementation of gonadotropin‐releasing hormone (GnRH) analogs for ovarian protection in women receiving chemotherapy among fertility preservation facilities in Japan.
Shina Sakaguchi +3 more
wiley +1 more source
Use of anti-mullerian hormone to select for fertility in beef heifers [PDF]
A study was conducted to determine whether concentration of serum Anti-Mullerian Hormone (AMH) at weaning and/or breeding could predict subsequent fertility in beef heifers.
Newberry, Hannah
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The detection, treatment, and biology of epithelial ovarian cancer [PDF]
Ovarian cancer is particularly insidious in nature. Its ability to go undetected until late stages coupled with its non-descript signs and symptoms make it the seventh leading cause of cancer related deaths in women.
Jennifer A.A. Gubbels +4 more
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Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function [PDF]
Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed.
Abedel-Majed, Mohamed A. +3 more
core +1 more source
Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Campbell, David +7 more
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Notch3 targeting. A novel weapon against ovarian cancer stem cells [PDF]
Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models.
Bellavia, Diana +5 more
core +1 more source
Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
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