Results 31 to 40 of about 138,110 (219)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Multi-Objective Optimization Benchmarking Using DSCTool

Mathematics, 2020
By performing data analysis, statistical approaches are highly welcome to explore the data. Nowadays with the increases in computational power and the availability of big data in different domains, it is not enough to perform exploratory data analysis ...
Peter Korošec, Tome Eftimov
doaj   +1 more source

RETRACTED: A Novel Cooperation Multi-Objective Optimization Approach: Multi-Swarm Multi-Objective Evolutionary Algorithm Based on Decomposition (MSMOEA/D)

Frontiers in Energy Research, 2022
In order to achieve good adaptability, medical bone implants for clinical applications need to have porous characteristics. From a biological and mechanical point of view, the design of porous structures requires both suitable porosities to facilitate ...
Rui Liu, Hanning Chen, Zhixue Wang, Yabao Hu   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Multi-Objective BiLevel Optimization by Bayesian Optimization

Algorithms
In a multi-objective optimization problem, a decision maker has more than one objective to optimize. In a bilevel optimization problem, there are the following two decision-makers in a hierarchy: a leader who makes the first decision and a follower who ...
Vedat Dogan, Steven Prestwich
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A new multi objective crested porcupines optimization algorithm for solving optimization problems

Scientific Reports
This paper presents a new multi-objective optimization algorithm called the Multi-Objective Crested Porcupines Optimization (MOCPO) Algorithm, which uses an elitist, non-dominated sorting and crowding distance mechanism.
Divya Adalja, Pinank Patel, Nikunj Mashru, Pradeep Jangir, Arpita, Reena Jangid, G. Gulothungan, Mohammad Khishe   +7 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Recent advances in multi-objective whale optimization algorithm, its versions and applications

Journal of King Saud University: Computer and Information Sciences
Multi-objective optimization (MO) addresses problems involving multiple conflicting objectives, requiring effective techniques to identify Pareto optimal solutions. Among the numerous MO approaches, the Multi-Objective Whale Optimization Algorithm (MOWOA)
Sharif Naser Makhadmeh, Sofian Kassaymeh, Gaith Rjoub, Bilal Bataineh, Yousef Sanjalawe, Mohammed Azmi Al-Betar   +5 more
doaj   +1 more source