Results 91 to 100 of about 3,649,841 (297)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Multi-actor and place-driven leadership in city-based efforts to improve well-being: a transnational perspective [PDF]
This paper explores three exemplar place-based initiatives (PBIs), Logan Together (Australia), Living SJ (Canada) and The Southern Initiative (TSI) (New Zealand), to identify place leaders and the practices they enact alone, and together, to drive well ...
Boorman, Cathy, Jackson, Brad
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Transitions of power in multi-actor information system projects [PDF]
, 2017 Power and politics play an important role in multi-actor information systems where balancing change and stability can become a goal in itself. To investigate this, the paper looks at a project on the implementation of the electronic system of business ...
Endrit Kromidha +2 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Boosting organic seed and Plant breeding across Europe 2017‐2021: A multi‐actor approach [PDF]
, 2019 Boosting organic seed and Plant breeding across Europe 2017‐2021: A multi‐actor ...
Monika, Messmer, Moeskops, Bram
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Decentralized Multi-Agent Advantage Actor-Critic
, 2022 We present a decentralized advantage actor-critic algorithm that utilizes learning agents in parallel environments with synchronous gradient descent. This approach decorrelates agents’ experiences, stabilizing observations and eliminating the need for a ...
Scott Barnes (12081710)
core +1 more source
De meerwaarde van multi-actor-onderzoek
: In een multi-actor onderzoek worden meerdere leden van een sociaal systeem bestudeerd om een vollediger beeld te krijgen van complexe sociale fenomenen. In een samenleving gekenmerkt door toenemende diversiteit (zowel van grotere leefgemeenschappen als
Claessens, Elke, De Laet, Romy
core +1 more source