Results 91 to 100 of about 41,118 (312)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
The ‘policy mix’ for innovation: rethinking innovation policy in a multi-level, multi-actor context [PDF]
Recent years have seen the emergence, take-up and use of the term 'policy mix' by innovation policy makers and by policy analysts & scholars alike. Imported from economic policy debates, the term implies a focus on the interactions and interdependencies ...
Flanagan, Kieron +2 more
core +1 more source
Collaboration and complexity: an experiment on the effect of multi-actor coupled design [PDF]
, 2016 Design of complex systems requires collaborative teams to overcome limitations of individuals; however, teamwork contributes new sources of complexity related to information exchange among members.
De Weck, Olivier L, Grogan, Paul T.
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Results of multi-actor collaboration in risk analysis: a simplified risk assessment toolkit for rapid detection of emerging risks. [PDF]
EFSA J, 2023 Meerpoel C +5 more
europepmc +1 more source
Developing rainfed crop-livestock value chains through Innovation Platforms: experiences with rural communities in the Volta Basin [PDF]
, 2013 Multi-actor system as an Innovation Platform (IP) The Challenge Program on Water and Food in the Volta basin aims “to strengthen integrated management of rainwater and small reservoirs so that they can be used equitably for multiple uses.” One way by ...
Some, Hubert W.
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