Results 81 to 90 of about 3,649,841 (297)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cooperative Multi-Agent Reinforcement Learning With Approximate Model Learning

IEEE Access, 2020
In multi-agent reinforcement learning, it is essential for agents to learn communication protocol to optimize collaboration policies and to solve unstable learning problems.
Young Joon Park, Young Jae Lee, Seoung Bum Kim   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Talk-and-Action Approach to Citizenship Education. An Outline of a Methodology of Critical Studies in Citizenship Education

Journal of Social Science Education, 2008
The present research on the development of citizenship education in (transformation) countries fails to ac-knowledge that systems of citizenship education are political organisations by nature. This research does not analyse citizenship education (CE) as
Reinhold Hedtke, Tatjana Zimenkova
doaj   +1 more source

Predicting Multi-actor collaborations using Hypergraphs

CoRR, 2014
Social networks are now ubiquitous and most of them contain interactions involving multiple actors (groups) like author collaborations, teams or emails in an organizations, etc. Hypergraphs are natural structures to effectively capture multi-actor interactions which conventional dyadic graphs fail to capture.
Ankit Sharma 0004, Jaideep Srivastava, Abhishek Chandra   +2 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Everything about climate change is disproportionate: Principles for spatial justice in urban climate action

Geo: Geography and Environment
As climate change makes the future of urban living appear increasingly daunting, many people and communities are already experiencing climate impacts.
J. E. Goncalves, N. Narendra, T. Verma
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The ‘policy mix’ for innovation: rethinking innovation policy in a multi-level, multi-actor context [PDF]

Recent years have seen the emergence, take-up and use of the term 'policy mix' by innovation policy makers and by policy analysts & scholars alike. Imported from economic policy debates, the term implies a focus on the interactions and interdependencies ...
Flanagan, Kieron, Laranja, Manuel, Uyarra, Elvira   +2 more
core  

Ironi Sampah dan Pariwisata: Respon Multiaktor atas Krisis Sampah di Kawasan Wisata Kaliurang

Gadjah Mada Journal of Tourism Studies
The massive development of tourism in the Kaliurang area of Yogyakarta over several decades has had a significant impact on environmental changes, both physical and non-physical.
Runavia Mulyasari, Vania Sekar Widyawati
doaj   +1 more source