Results 81 to 90 of about 41,118 (312)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Social policy and international interventions in South East Europe: conclusions [PDF]

open access: yes, 2007
This book has brought together three fields of study; that concerned with the role of international actors and their influence on national polices; changes taking place to social policies in the context of globalisation, transnationalism and ...
Deacon, Bob   +2 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Multi-actor regional governance: regions as new players for innovation in Europe [PDF]

open access: yes
In recent years, new regionally based strategy building processes emerged at the interface between public policy and the social coordination of collective action. Foresight as a governance process for stimulating regional innovation and for strengthening
Knut Koschatzky, Vivien Lo
core  

The Master model on multi-actor and multilevel social responsibilities [PDF]

open access: yes, 2011
This working paper contributes to a collective discussion in a workshop occurring in January 2011 at the International Institute of Social Studies, bringing scholars from Europe and Brazil and aiming inter-university research collaboration on linking ...
Ashley, P.A. (Patricia Almeida)
core  

Examining the interaction between vertical and horizontal dimensions of state transformation

open access: yes, 2009
Two dimensions of state transformation often analysed separately can be identified as vertical authority shifts between different levels of government and horizontal authority transfers between state and non-state domains.
Büchs, Milena
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

On the right track? : evaluation as a tool to guide spatial transitions [PDF]

open access: yes, 2015
Spatial developments are becoming more and more non-linear, dynamic and complex with a wide range of possible actors. The awareness of uncertainty in spatial planning is growing and therefore, projects need to integrate a high level of flexibility.
Boelens, Luuk, Pisman, Ann, Terryn, Els
core   +1 more source

Nonresponse of secondary respondents in multi-actor surveys: Determinants, consequences, and possible remedies [PDF]

open access: yes, 2011
Multi-actor survey data are highly valuable for answering questions about family relations, but the collection of such data is complicated by nonresponse among secondary (nonresident) respondents.
Aart C. Liefbroer   +7 more
core   +4 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

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