Results 61 to 70 of about 3,649,841 (297)
Capabilities for advanced services: A multi-actor perspective [PDF]
Industrial Marketing Management, 2017 Servitization involves manufacturers developing service offerings to grow revenue and profit. Advanced services, in particular, can facilitate a more service-focused organization and impact customers' business processes significantly. However, approaches to servitization are often discussed solely from the manufacturer's perspective; overlooking the ...
Vicky M. Story +4 more
openaire +4 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Actor-only in comparison with actor-critic learning.
, 2019 The columns labeled with ‘action value 1’ (panels a and d) and ‘action value 2’ (panels b and d) show the simulated evolution of the collective synaptic weights G and N of the actor network over 30 successive trials.
Rafal Bogacz (307953) +1 more
core +1 more source
Scientific ReportsEconomic costs of climate change are conventionally assessed at the aggregated global and national levels, while adaptation is local. When present, regionalised assessments are confined to direct damages, hindered by both data and models’ limitations ...
Ignasi Cortés Arbués +5 more
doaj +1 more source
Raumforschung und Raumordnung, 2023 Public space is an essential element of cities as it offers several benefits. Due to its significance, there is much discussion of its design, development and use.
Dahae Lee
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Evaluation in Multi-Actor Policy Processes [PDF]
Evaluation, 2006 Two main functions of evaluation are enabling accountability and collective learning. Both of these – and their combination – run into diverse complications when applied in complex multi-actor policy processes. The article explores these complications and illustrates them with examples from the field of spatial policy.
van der Meer, Frans-Bauke +1 more
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
European Transport Research Review, 2018 Purpose A family of innovative financial mechanisms and tools for urban public transport, based on the value increment caused by enhanced accessibility, are lately gaining much popularity as a solution to the challenges posed by public financial ...
Anastasia Roukouni +4 more
doaj +1 more source